Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
NOTE: This guide is mostly done for what items to buy and what do to in the game, the masteries and runes are optional.
Spell flux does alot of damage to champions and can give u lots of money trough minions to fast get your archangel staff. If the other champions are mid or low on health when you get to lvl 3 you can easy get the first blood if u have a decent champion with you. Just use Rune prison - Spell flux - Overload in that order.
Now you should have the Archangel staff, Boots of swiftness and Lich bane. In the mid game it's time to do some serious ganking. If you alert your allies that you are about to gank them and they attack at the same time, u can easily get 2 champions if they help you. Just use Desperate Power - Rune Prison - Spell Flux - Overload in that order.
Keep going for their champions cuz you can get champions that isn't tanks down to 10-30% hp with all your abilities alone.
The whole game
Use spell flux to get last hits on minions and use your abilities very often after you have gotten your archangel staff. If you are getting chased by a champion use your Rune prison to make him stand still for 1-2 sec. This build needs you to farm minions. You also have to use your abilities very often because of the Archangel staff.
This is not suppose to be a great guide but this is what I use to be extremely strong in games.
I like the utility masteries but I think almost everything works with this build because it barely matters in the late game with this build because it's all about the ability power which gets up to around 600+ ability power in the late game.
I'm only summoner lvl 14 and haven't bought runes yet so I don't know about which runes is good for this build but I would say ability power. I know mana regen is important for this build too but runes doesn't give that much extra mana regen.