Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Keeping this short- I'll update it tomorrow when it's not 1:20 AM
OK, with the new ryze changes, AP no longer scales quite as well as it used to. Overload scales 10% with mana, and Rune Prison 5%, which, with the large amounts of mana items currently in the game, means you can stack near 5k mana Late game, translating to 450-500 damage, and 225-250 damage respectively on your overload and Rune Prison. Because of this, AP scaling is now much lower on all of his abilities, and their damage has been cut across the board.
Since I'm tired, and assume most of you know how to play league at some level:
1. Build mana items off the bat. Mana = Damage.
2. Build mana -Survivability items, as shown above, that give you a tanky feel, while still letting you do carry-levels of dps.
3. Proceed to have near if not at 40% CDR, and spam q, another ability, Q, another ability, so on so forth. Nuke rotation is R, Q as quickly as possible after R, w, q, e ,q, then as they come back up. USE Q WHENEVER IT IS OFF CD.
Ok sleep time. The item build is, in my opinion, how it should be done now. Straight AP leaves him lackluster, missing most of his damage, and allowing him to be shut down easily.
I'll update it tomorrow!