Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
This is a basic build I came up with for Ryze. The idea behind it is to stay behind Blitzcrank and let him bring the other champions to you. This seems to work very well for my friend and I; for at the start of match, any soul dumb enough to come in range of us and our tower will always die a very painful death. Our trick is Blitzcrank leads with a pull that gets them in range of our tower followed with a pop up if he's level 2. My Job right after is to Rune Prison right after he gets pulled so the tower gets atleast two shots in and then blast him with my might red Orb of Doom otherwise known as Overload. By then hes either about to get popped back up in the air again by Blitzcrank or he's dead. We continue to do this in various different ways, sometimes with Ryze leading with the Rune Prison and then the pull or maybe a Pull through a wall to join us for a Huge party of smack the pinata. I'm not going to go to in-depth with how to play this combo because what would be the fun if we just had a bunch of people copying us. As far as items go I leave the last items up to choice depending on the fight; if it last that long, but almost always end up getting rid of Dorian's Ring for something that'll grant more Ability Power. As always this build isn't perfected yet as there's always something more to make something better. If I figure anything out I'll Re-Edit this. Enjoy and have fun raping face.