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Not a crazy threat but can still slow you during 2v2 fights. Take extreme care at 6 as Ashe will most likely send an arrow your way followed up by heavy support cc
Caitlyn
Her range is superior to your by far. If the support has a root you can be into a perma root situation with her W. Only way to contest her is with a gank or a hard CC champion like Pantheon or Nautilus.
Ezreal
Ezreal is very strong in the current Meta. Make sure to dodge his E and W and you should be fine. It will be hard to catch him out if he has his E but otherwise just try to play around it.
Aphelios
Just take care for his bust damage and you should be fine to farm under turret.
Draven
Draven's extremely strong early game will destroy your extremely weak early game. Most games will result in Draven getting fed if you don't play perfectly.
Miss Fortune
Just take care for her E catching you out in lane. She should beat you arely but at 6 if you dodge her R you should win depending on the support.
Samira
I always tend to ban Samira as her champion is just better than vayne early and her dash can create and easy kill onto you if your not careful.
Senna
As long as you dodge her E it should be a free lane depending on the support.
Jhin
Jhin will be able to bully you out to your turret in most scenario's and if your not careful will be able to poke you low enough for his R.
Twitch
Twitch isn't very strong early but will still kill you in most scenarios if you aren't careful for his q. If you hit a successful E you will be able to kill him easily.
Kog'Maw
Care for extra range he can gain to poke you out. Depending on how fed he is this lane can go either way.
Lucian
His extreme burst will kill you 90% of the time if you don't care for it. If his support root or stuns you, you can say goodbye to your health bar.
Tristana
Care for her burst damage with her Q and E, and heavy engage with her W. She should beat you in laning phase but if you aren't too far behind you should be able to beat her late game.
Yasuo
Yasuo usually will play bot with a Nautilus or Malphite support intending to kill you over and over again at 6. Yasuo's mostly bring ignite with support taking exhaust or heal. Care for the melee burst with his E-Q + Ignite. After 6 take extreme caution for a support sitting in the bush waiting to flash knock you up.
Kalista
Should be an easy farm lane but watch out for the heavy engage with her R or a jungle who will try to camp you.
Sivir
Although Sivir is very weak right now she should still be able to beat you in lane as you can be very weak early. Saying this she is still beatable in lane but can be difficult. Late game you should beat her most of the time depending on how fed she is.
Varus
Varus will try to poke you out with his Q so make sure to save your Q for when he starts to charge it up. Once he hits 6 if you dodge his R should be a free win.
Xayah
Xayah is pretty weak right now so you should be able to farm and beat her in lane. Just make sure tom watch out for her E Root.
Soraka
Soraka's heal is very good with Vayne when she Ults.
Yuumi
Yuumi is very strong with Vayne as she can heal Vayne giving her high amounts of movement speed and can Ult to stop the enemy ADC from kiting.
Lulu
Lulu's Ult and attack Speed Burst will help Vayne kill and enemy in seconds with her high burst. This will also keep Vayne alive in teamfights.
Veigar
His E is very helpful with your E for an easy stun.
Leona
Leona support is just very strong with high amounts of CC to help peel for Vayne against an enemy Assasin or an engage support.
Synergies
IdealStrongOkLowNone
Soraka
Soraka's heal is very good with Vayne when she Ults.
Yuumi
Yuumi is very strong with Vayne as she can heal Vayne giving her high amounts of movement speed and can Ult to stop the enemy ADC from kiting.
Lulu
Lulu's Ult and attack Speed Burst will help Vayne kill and enemy in seconds with her high burst. This will also keep Vayne alive in teamfights.
Veigar
His E is very helpful with your E for an easy stun.
Leona
Leona support is just very strong with high amounts of CC to help peel for Vayne against an enemy Assasin or an engage support.
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