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Orb does true damage upon return and until you get lifesteal she can outsustain you with her passive. Try to rush 6 before her since she can easily ult away from you post 6.
Akali
Akali has one of the worst early games in League of Legends. Being melee and having next to no wave clear, you can easily deny her cs. I recommend pushing in fast and harassing her under tower, this prevents her from roaming and getting any kills. When you ult place down a pink so you can unleash your full combo.
Anivia
This bird is insanely hard to kill due to her egg passive. Try and force early fights when she is still squishy. If you don't win early, try to have your jungler cover mid while you roam.
Annie
Although Annie is fairly immobile her burst is massive and coupled with a stun. Try and predict when she'll try and stun you and dodge it with your ult.
Azir
Don't disregard the amount of poke Azir's soldiers can dish out. Often times Azir will try to use his ult to block you off when you death mark, save living shadow to simply go past his wall.
Brand
Don't stay near minions as his ultimate will bounce off of them. Pillar of fire is hard to doge so try and use living shadow to get away with it. Try not to let him push you under tower.
Cassiopeia
Most Cassiopeia's will ult as soon as you appear. You can bait the ult out or just count on her wiffing it as Zed's ulti positions him behind his target champion.
Cho'Gath
Cho Gath is a pain for Zed to deal with. Tankiness, utility and a true damage ult, what could be worse? Try to win fights early otherwise it will get extremely hard to kill him.
Diana
Diana will outscale you late game but is reliant on landing her q which you can dodge easily
Ekko
After the Ekko nerfs, he is not that much of a threat anymore. You can outsustain him, just ensure that you don't get caught in his ultimate.
Elise
Elise's rappel will NOT cancel your ult damage, however it can prevent you from landing any spells. If you can bait out the rappel first, her low mobility will allow you to easily get your full combo off.
Ezreal
When you ult, follow his arcane shift with your living shadow.
Fiddlesticks
Early game, Fiddle will easily drain you to no end. Spam the missing ping when he roams and ult him after he's used his fear and/or silence. Ignite will help cut his healing down.
Fizz
Same with other late game champions, you can stomp him hard early. Force him under tower and bombard him with constant shurikens. WIthout wave clear, he'll miss tons of cs. Keep track of his E and ult him if he uses it. Dodge his ultimate with shadow/ult if he tries to engage on you with it.
Galio
Galio is not seen often, and isn't much of a threat since you're ad. The only thing to be wary of is diving him under tower since his ult will taunt you and you'll start taking turret agrro.
Gragas
Body slam and explosive cask can easily disengage Death Mark. Without life steal, Gragas will also outsustain you due to his passive.
Heimerdinger
Fortunately Zed's passive allows him to last hit under turret. You should be able to all in Heimer post 6 as long as he doesn't have his hourglass yet.
Karma
Karma has many tools to deal with you. Her shield and movement speed buff along with her tether/root will keep her pretty safe from your deathmark. Try to manage her cooldowns and push the lane so you aren't trying to farm under tower with her poke.
Karthus
No escape, but beware of requiem as he can easily rack up kills. Try and kill him in the 3 seconds he's stuck channeling.
Kassadin
Easy early game and his magic shield will be useless against your ad.
Katarina
Your ult can negate her ult
Kayle
Kha'Zix
Kog'Maw
LeBlanc
Lee Sin
Lissandra
Lulu
Lux
Malzahar
Master Yi
Morgana
Nidalee
Nunu & Willump
His heal and iceballs will be annoying so ensure that you have ignite when you all in.
Orianna
Riven
Syndra
Her whole burst can be avoided by ulting. She has no answer to your onslaught other than an unreliable stun.
Talon
Talon's poke is much easier to land than Zed's shurikens. His burst is almost unavoidable due to his onclick gap closer. His ult is also on a much lower cooldown than Zed's. Even if Zed engages with his ultimate, Talon can ulti to escape. Pinks will help but it would be better just to roam.
Teemo
Teemo's blind won't save him. It may be pesky when you're trying to use your passive to farm but otherwise, move quick isn't enough to kite Zed.
Twisted Fate
TF's early game is pretty bad. You'll be able to destroy him then. Also if you time it right, ulting him while he is ulting will cause you to follow him.
Urgot
Like Cho'gath, Urgot's lock on poke can hit you from an insane range if he lands his poison. His ult also will negate yours.
Varus
Veigar
After the nerfs to Veigar's stun, it is easy to see it coming. Since you aren't AP, you won't take as much damage from his ultimate and you can even negate it with yours.
Vel'Koz
Vel'Koz is immobile and doesn't have reliable cc to stop Death Mark. You can dodge his ultimate or his knock up with your shadows. The only thing to be wary of is his q poke and the 3 stack true damage passive.
Viktor
Vladimir
Vlad can easily pool to stop your ultimate, his sustain will beat yours. The best thing to do in this scenario is to push him under tower early so he has a hard time farming.
Xerath
Yasuo
This is more of a skill matchup, however Zed has the edge. If you dodge the tornado you can effectively negate his ultimate. When poking use your e first to proc his shield passive before throwing your q out.
Zed
If you find yourself in a mirror match up, try to throw your shurikens so that you get the full damage (without minions in the way). Keep track of cooldowns and unless you're sure you can kill him, don't be the first to ult.
Ziggs
Ziggs is super squishy with a unreliable escape. As long as you don't eat all of his bombs, you should kill him easy.
Zilean
Zilian's ult does counter Zed's but he doesn't have the best poke along with his squishiness, he shouldn't stand a chance.
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