Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Threats to Vayne with this build
|Sivir||Pretty easy matchup, she can only spell shield your Condemn, and she usually won't be able to do so.|
I recommend this build to new Vayne players because the BoRK provides good lane sustain, AD to last hit with, attack speed to trade with easier, and the passive gives good damage to any tanks on the enemy team.
IE: Super high damage on squishies.
Rapid Firecannon: Buy when against champions you want to stay away from (e.g Caitlyn + Azir, Tristana + Lux, Draven + Syndra + Nidalee).
Statikk Shiv: Buy if your team lacks waveclear.
Mercurial Scimitar: Lots of CC on the enemy team.
Bloodthirster: Really good lifesteal, nothing else to say.
Death's Dance: Buy if you are getting blown up by assassins over and over, otherwise Bloodthirster is usually the better option.
Mortal Reminder: Personal favorite for damage against tanks that heal (e.g Maokai, Mundo, Zac, etc.).
Guardian Angel: Buy for the same reason you would buy Death's Dance.
Guinsoo's Rageblade: Stacking with BoRK passive and Silver Bolts makes for a fun way to play while ahead, it's not a very good item on Vayne though because you waste all of the AP.
Wit's End: Buy with Rageblade or to MR Shred for your fed APC.