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He scales a lot late game (health wise) and is very hard for Akali to counter.
Urgot
He starts pretty strong early game unlike Akali, meaning it's much harder to counter him until late game. Late game he has lots of health which also means that Akali will have a hard time countering him.
Riven
She starts off pretty strong early game which is the complete opposite to Akali, as well as her abiloty to gain shield giving Akali an overall hard time against her.
Yorick
Massive threat to Akali, he scales so much and due to his ability to havehis "little pet", it is almost impossible for Akali to win in such match up.
Nasus
Also lots of health, cc, and overall is really annoying. Make sure you have very high damage so that Akali can stand a chance of defeating him.
Kled
He is very annoying type of champion because he has so much extra health and he starts off quite strong early game which is a challenge for Akali.
Wukong
His illusions and constant attacks make it practically impossible to counter him, personally I always have a hard time playing stay-safe against Wukong.
Ornn
Has lots of health BUT is very easily countered if you dodge all of his attacks.
Garen
He starts off pretty strong but Akali scales a lot mid/late game so it is a relatively easy counter.
Illaoi
Yet again lots of health and has a very strong start which is major trouble for Akali.
Cho'Gath
He can scale to a tremendous amounts of health which will make it impossible to kill him unless Akali has high damage. It is very important to not let him get fed early game.
Kayle
Kayle starts off extremely weak and mana wasteful early game, which is a win for Akali. However, she scales massively the moment she gets her ult on level 6 and becomes long ranged. She becomes even more dangerous at level 11 as her basic attack will do more damage thanks to her passive. Akali will have to dodge all of her CC attacks to quickly execute her which is quite a challenge.
Sett
His attacks give him extra health which will heavily counter Akali as she has to wait for her energy to recharge, unlike Sett who can usually continue with his attacks. It is important to dodge his attacks and execute him quickly so that he doesn't have a chance to gain extra health from his abilities or life steal.
Malphite
He starts off relatively weak early game, so there should be no problem for Akali to slowly scale. He gains lots of health mid/late game so it's important that Akali has relatively high damage to kill him.
Renekton
His life steal is hard for Akali to counter, overall he is incredibly strong early and late game. The best way to deal with such match up is to have the jungler help Akali in lane.
Gnar
Gnar's rage mode is the biggest problem for Akali. Overall, he starts off really strong so Akali will have to play stay safe under turret to have a chance for surviving. It is the best to suddenly attack Gnar when he is not massive in size and does not have the ability to change either.
Mordekaiser
With Morde, it is slightly a Russian Roulette, sometimes it is extremely easy to counter him once Akali gets her ult at level 6, however that is only possible if he is not fed at the early stages of the game. Late game it is a hard champion to counter for Akali because of his ultimate, however it is possible if Akali scales a lot.
Tryndamere
He is invincible when he is in undying rage, however it is best to get him to low health before he goes into rage and then avoid his attacks with Akali's E or W skill. Once Tryndamere is out of rage mode, Akali needs to attack him immediately to finish him off.
Jax
His life steal and stun abilities are a threat to Akali but if avoided, Akali has a relatively high chance of countering him.
Volibear
He scales in health a lot and has a strong start. It is best to have a jungler help Akali out with this one.
Camille
Camille is a very easy kill for Akali if all of her attacks are dodged, sudden impact of Akali's attacks will execute Camille before she knows it.
Aatrox
He starts off relatively strong so it's best to wait for Akali to scale a little. If all of his attacks are avoided, he should be an easy kill.
Darius
His life steal is quite huge and his bleeding stacks from his passive will have a huge impact on Akali. He is quite hard to counter but Akali has a much higher chance once she (even slightly) scales (for example gains her ultimate on level 6).
Sylas
Due to his life steal it is an almost impossible task for Akali to win lane and kill Sylas, it is always best to have the jungler help Akali out when Sylas pushes up (to tower especially).
Heimerdinger
His constant, mostly remote attacks are very hard for Akali to counter, so she will certainly need some help to deal with this champion.
Xin Zhao
Will help out Akali a lot against hard matches, however has a high probability of stealing Akali's kill(s).
Fiddlesticks
Will help out Akali and work well with her due to his lifesteal but it may not be enough for some tough, high health matches.
Hecarim
Certainly a good match to help out Akali if she has a tough match up or overall is having a hard time. However, he has a big potential to steal Akali's kills as he does a sudden burst of damage.
Evelynn
Her charm (if hit) is huge help for Akali to go for the kill and advance forward. Overall, Evelynn's sudden burst of damage (such as her E and W skills) will hugely aid Akali in her lane and in general in team fights.
Kayn
His sudden damage and CC (crowd control) makes him and Akali a great duo. They both scale mid/late game, however Kayn is of help to Akali early game as well because of his W CC ability and a scaling ultimate.
Katarina
Katarina can always help out Akali against high health enemies because of her passive and her ultimate (which can have its cooldown reset if an enemy champion is killed with it)
Diana
Due to Diana having a recastable E ability and a scaling ultimate, her and Akali make a great team in battling any high damage and high heath enemies. Akali's swift attacks will give her a higher chance of stealing Diana's kill(s).
Master Yi
His Q can do insane amounts of damage which will help Akali execute high health match ups and win team fights.
Lee Sin
Lee Sin is able to kick enemies into tower which will greatly help Akali gain kills as the tower will attack any enemy champions that will try and attack Akali and Lee Sin. Lee Sin's abilities can also give Akali a shield which will protect her from incoming attacks.
Morgana
Her Q, E and W abilities will allow Akali to deal damage while an enemy is rooted or avoid being impacted by any abilities as Morgana's shield will make Akali immune.
Warwick
His life steal and stun attack will allow Akali to deal damage while an enemy will be also attacked by WW. This will give Akali a chance of killing a high health/damage enemy.
Synergies
IdealStrongOkLowNone
Xin Zhao
Will help out Akali a lot against hard matches, however has a high probability of stealing Akali's kill(s).
Fiddlesticks
Will help out Akali and work well with her due to his lifesteal but it may not be enough for some tough, high health matches.
Hecarim
Certainly a good match to help out Akali if she has a tough match up or overall is having a hard time. However, he has a big potential to steal Akali's kills as he does a sudden burst of damage.
Evelynn
Her charm (if hit) is huge help for Akali to go for the kill and advance forward. Overall, Evelynn's sudden burst of damage (such as her E and W skills) will hugely aid Akali in her lane and in general in team fights.
Kayn
His sudden damage and CC (crowd control) makes him and Akali a great duo. They both scale mid/late game, however Kayn is of help to Akali early game as well because of his W CC ability and a scaling ultimate.
Katarina
Katarina can always help out Akali against high health enemies because of her passive and her ultimate (which can have its cooldown reset if an enemy champion is killed with it)
Diana
Due to Diana having a recastable E ability and a scaling ultimate, her and Akali make a great team in battling any high damage and high heath enemies. Akali's swift attacks will give her a higher chance of stealing Diana's kill(s).
Master Yi
His Q can do insane amounts of damage which will help Akali execute high health match ups and win team fights.
Lee Sin
Lee Sin is able to kick enemies into tower which will greatly help Akali gain kills as the tower will attack any enemy champions that will try and attack Akali and Lee Sin. Lee Sin's abilities can also give Akali a shield which will protect her from incoming attacks.
Morgana
Her Q, E and W abilities will allow Akali to deal damage while an enemy is rooted or avoid being impacted by any abilities as Morgana's shield will make Akali immune.
Warwick
His life steal and stun attack will allow Akali to deal damage while an enemy will be also attacked by WW. This will give Akali a chance of killing a high health/damage enemy.
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