When playing Ezreal you should be comfortable with skill shots. All, but his third ability, are skill shots. The combo for his skills should always have his mystic shot first and last in the sequence. This way to ensure maximum damage and the cool-down with its passive. He is very weak in health so try to stay out of the way in team battles. And Always shoot his ult off when ever possible. Mystic shot should bring the cool-down on it fast enough.

When mid always try to get arcane shift to hit and then his other spells. It does a lot of damage and will set up for the rest of his abilities. The instant flash can also confuse most characters and make them mis their skill shots or miss click

When in lane- always watch what your partner is doing. Ez can rush in with arcane shift to help out and do damage. Try to get mystic shot on the enemy as much as possible. Mystic shot does good damage and great harassment.

When play in in a lane or mid, use the ult to finish off enemies. Always watch out for your teammates to see if you can shoot the ult to help them out. It goes across the map, so shoot even when far away. Even in team fights, shoot it when the enemy is bunched together and do lots of damage. Ez has no stun, but makes up for it with lots of damage.