Avoid at all cost. She is the highest level of skill check and I promise you getting ahead of her will not be enough.
Tristana
Pick another champ or take the penalty timer. The only way you're winning this is a god send support that's waiting every time for her to jump.
Lucian
Dash, Dash, Dash Dead. (You were dead by the 2nd dash but it wasn't announced till your support was dead.)
Akshan
One of the many mobility champs that will out pace Senna in a 1v1 early game.
Draven
DON'T FEED THIS FUCK!!!!!! nuf said
Kindred
Has more burst and can easily take the lead at the beginning.
Sivir
Checkers, because you two do have a rock paper scissors type of dynamic. Have a spell shield though does give her an advantage.
Ezreal
Hurts a lot and positioning can only take u so far. Bring a good support to help mitigate him.
Xayah
A cunt in a half, and she will check you if she doesn't wreck you.
Aphelios
You can harass him early game but he will grow in strength the longer the game goes.
Twitch
Stinky, stay under tower and good luck
Twisted Fate
Owwie
Kog'Maw
3d chess squared. Need I say more?
Miss Fortune
Starts even, will stay in her favor if she starts to get ahead.
Vayne
Take this with a grain of salt. She's a skill check
Caitlyn
You will go 1:1 with her in most scenarios. Especially late game.
Varus
SNIPE OOOOOOOOOFFF more or less literally.
Ashe
Can be a pretty even match up it usually depends on your positioning skills.
Kalista
Pretty decent match up. The better their partnership the harder it will be.
Jhin
He's a sniper sort of like senna, but he's easier to abuse than Caitlyn.
Jinx
Take the 1v1 most all the time. Even if she get's fed you will come back and put her back in her place.
Samira
Childs play, harassment in the best way, playground games, like making Bruce Wayne an orphan, E Z oh your dead.
Amumu
Do you need an in-depth explanation why an Amumu supp is OPAF?
Xerath
Lord bless the mental states of the person facing this combo.
Swain
This is true proof you and your partner believe you are better than most the players in the match and know the later the game the bigger your expanse.
Veigar
Just like in the card game, this dynamic duo is none for inflicting lots of pain, CC, and control over your enemy. Make them dance for your entertainment.
Malphite
You already know how this one goes. FOOOOOOOOOOOOOOURR
Zyra
I just don't like laning against her so I know as a support she would be a nightmare.
Lux
You will be hated. You will be expected in hell. You might get false reported. If they have an assassin just snipe everyone before they even see you guys after level 6.
Pantheon
Bing Bong, they're dead.
Blitzcrank
Immaculate, scrumptious, delicious, not even a question here.
Leona
Even Sol might see this as trolling, or punishment. Just don't be too toxic cause this combo is known to get you focused after the stun-lock.
Morgana
Vile, putrid, nasty, sour. People will actually have time to play on their phone with this combo. Of course it's still based on your supports abilities but the money is still pretty free here.
Ornn
7. Seconds. Of. C. C. and upgrades
Neeko
A skilled Neeko can make you something to be feared by all enemies in the match. A decent one can set you up often enough to finish bursting your enemy down.
Thresh
Enemies make the best partners and these 2 are quite honestly an un-deadly combo. Very easy synergy and there's nothing more iconic.
Pyke
Send them to ripper docks with this spicy combo.
Shaco
No data for this pairing but I can only imagine they would work decently well if you goal is just to inflict mental dmg. A very tilt oriented combo.
Ziggs
The burst dmg here is immaculate. Just be sure you remember you two are squishy.
Nautilus
Can be a pretty easy match as long as you can finish whatever he catches.
Seraphine
The amount of range advantage you will have in this combo will really fuck most any engage. Just don't get cc'd before them.
Sett
He's daddy for a reason. He can get poked for quite a bit before inflicting massive dmg with you. A great pick for engage heave duos or assassins.
Galio
Smack, Smack, Smack Attack! he'll allow you to be aggressive during the beginning and keep the enemy cc'd long enough for your combined dmg to take out their squishy.
Brand
A lot of burst potential, very easy to become the support in this combo but if brand get's fed you'll catch up with him eventually and win anyway.
Soraka
It's Sorarka. Easy value even if she isn't rooting enemies every team fight.
Anivia
Actually one of the better support combos on the list. If they can use the wall as deadly as their stun they won't stand a chance.
Ashe
Not recommended but go for it if you want. Make your enemies cry frozen tears.
Sona
People will really sleep on movement speed till y'all mow them down trojan horse style. It can work but isn't the best.
Ahri
Hard CC = more GG. You do have to have a bond with your partner for this to work since timing and call outs need to be pretty precise, but lots of burst potential here.
Vex
YOU MUST OUT POKE YOUR ENEMY! I can not stress this enough with this duo. If your opponents are dive champs Vex is a decent counter but you must out poke your enemies if you choose this pair.
Nami
Being in sync for these two will have to be a must, because they realistically aren't the best together. it can be hard to work these 2 together but when they work, they REALLY work.
Rakan
This probably works. There isn't any data I can give you on this combo but in theory it should work. Especially after 6.
Poppy
Surprisingly well, especially if they're too dumb to stay away from walls. It isn't the easiest combo but it can be pretty fun.
Janna
I have very little experience with this combo but it is possible for these 2 to be a pretty oppressive combo. Just might need more coordination than a random you might not know.
Rell
It takes some setting up, depends how much dmg the Rell can mitigate before all-ining.
Lulu
Very little data for this synergy. I think it could work sort of depending on your lulu's skill on the champ. Lulu usually wants empower you to do your best and save you from whatever you enemy might do so gl.
Tahm Kench
This can work but if they poke your team down it might be a real tough battle.
Maokai
On of those picks that matter more on the support's ability to help set you up for kills than anything else.
Nunu & Willump
I guess. There's honestly very little data for this combo. It depends primarily on your support's set up but it is a possibility.
Yuumi
I don't like Yummi but she has her team potential, massive healing and sustain so I can't complain here.
Shen
This has no right being a viable option. It requires your partner to be able to communicate with you, a skilled partner, and outstanding positioning. If you didn't check yes to all of these you probably shouldn't attempt it for real.
Bard
Take this based on your partner synergy and the enemy duo. It's not the most viable partnership but it is a possible combination with play potential.
Orianna
No data for this combo, it is an option if you're looking for a sleeper cell powerhouse for late game. I don't think this a very viable combo but might as well try it.
Sejuani
Works better for Taric but I guess it could work if you really force it. The level 6 spike will be real for this one.
Braum
Seems like it should work, but he's mostly a meat shield with some cc abilities. It can work if you already have synergy with your partner.
Alistar
Is just a dmg magnet and can't really help unless they truly are an Alistar main.
Karma
Not ideal at all. It would be an all or nothing for both characters to go in and in most cases the hard cc would not help substantially enough to counter how much dmg is being done.
Kled
Can be played support, just not for Senna. Look to Lucian if you wanna try some tower dive hijinx, but definitely not here.
Taric
Don't do this to yourself please. You aren't gonna be near the fight. He's gonna get poked down. Look at literally any other pick.
Synergies
IdealStrongOkLowNone
Amumu
Do you need an in-depth explanation why an Amumu supp is OPAF?
Xerath
Lord bless the mental states of the person facing this combo.
Swain
This is true proof you and your partner believe you are better than most the players in the match and know the later the game the bigger your expanse.
Veigar
Just like in the card game, this dynamic duo is none for inflicting lots of pain, CC, and control over your enemy. Make them dance for your entertainment.
Malphite
You already know how this one goes. FOOOOOOOOOOOOOOURR
Zyra
I just don't like laning against her so I know as a support she would be a nightmare.
Lux
You will be hated. You will be expected in hell. You might get false reported. If they have an assassin just snipe everyone before they even see you guys after level 6.
Pantheon
Bing Bong, they're dead.
Blitzcrank
Immaculate, scrumptious, delicious, not even a question here.
Leona
Even Sol might see this as trolling, or punishment. Just don't be too toxic cause this combo is known to get you focused after the stun-lock.
Morgana
Vile, putrid, nasty, sour. People will actually have time to play on their phone with this combo. Of course it's still based on your supports abilities but the money is still pretty free here.
Ornn
7. Seconds. Of. C. C. and upgrades
Neeko
A skilled Neeko can make you something to be feared by all enemies in the match. A decent one can set you up often enough to finish bursting your enemy down.
Thresh
Enemies make the best partners and these 2 are quite honestly an un-deadly combo. Very easy synergy and there's nothing more iconic.
Pyke
Send them to ripper docks with this spicy combo.
Shaco
No data for this pairing but I can only imagine they would work decently well if you goal is just to inflict mental dmg. A very tilt oriented combo.
Ziggs
The burst dmg here is immaculate. Just be sure you remember you two are squishy.
Nautilus
Can be a pretty easy match as long as you can finish whatever he catches.
Seraphine
The amount of range advantage you will have in this combo will really fuck most any engage. Just don't get cc'd before them.
Sett
He's daddy for a reason. He can get poked for quite a bit before inflicting massive dmg with you. A great pick for engage heave duos or assassins.
Galio
Smack, Smack, Smack Attack! he'll allow you to be aggressive during the beginning and keep the enemy cc'd long enough for your combined dmg to take out their squishy.
Brand
A lot of burst potential, very easy to become the support in this combo but if brand get's fed you'll catch up with him eventually and win anyway.
Soraka
It's Sorarka. Easy value even if she isn't rooting enemies every team fight.
Anivia
Actually one of the better support combos on the list. If they can use the wall as deadly as their stun they won't stand a chance.
Ashe
Not recommended but go for it if you want. Make your enemies cry frozen tears.
Sona
People will really sleep on movement speed till y'all mow them down trojan horse style. It can work but isn't the best.
Ahri
Hard CC = more GG. You do have to have a bond with your partner for this to work since timing and call outs need to be pretty precise, but lots of burst potential here.
Vex
YOU MUST OUT POKE YOUR ENEMY! I can not stress this enough with this duo. If your opponents are dive champs Vex is a decent counter but you must out poke your enemies if you choose this pair.
Nami
Being in sync for these two will have to be a must, because they realistically aren't the best together. it can be hard to work these 2 together but when they work, they REALLY work.
Rakan
This probably works. There isn't any data I can give you on this combo but in theory it should work. Especially after 6.
Poppy
Surprisingly well, especially if they're too dumb to stay away from walls. It isn't the easiest combo but it can be pretty fun.
Janna
I have very little experience with this combo but it is possible for these 2 to be a pretty oppressive combo. Just might need more coordination than a random you might not know.
Rell
It takes some setting up, depends how much dmg the Rell can mitigate before all-ining.
Lulu
Very little data for this synergy. I think it could work sort of depending on your lulu's skill on the champ. Lulu usually wants empower you to do your best and save you from whatever you enemy might do so gl.
Tahm Kench
This can work but if they poke your team down it might be a real tough battle.
Maokai
On of those picks that matter more on the support's ability to help set you up for kills than anything else.
Nunu & Willump
I guess. There's honestly very little data for this combo. It depends primarily on your support's set up but it is a possibility.
Yuumi
I don't like Yummi but she has her team potential, massive healing and sustain so I can't complain here.
Shen
This has no right being a viable option. It requires your partner to be able to communicate with you, a skilled partner, and outstanding positioning. If you didn't check yes to all of these you probably shouldn't attempt it for real.
Bard
Take this based on your partner synergy and the enemy duo. It's not the most viable partnership but it is a possible combination with play potential.
Orianna
No data for this combo, it is an option if you're looking for a sleeper cell powerhouse for late game. I don't think this a very viable combo but might as well try it.
Sejuani
Works better for Taric but I guess it could work if you really force it. The level 6 spike will be real for this one.
Braum
Seems like it should work, but he's mostly a meat shield with some cc abilities. It can work if you already have synergy with your partner.
Alistar
Is just a dmg magnet and can't really help unless they truly are an Alistar main.
Karma
Not ideal at all. It would be an all or nothing for both characters to go in and in most cases the hard cc would not help substantially enough to counter how much dmg is being done.
Kled
Can be played support, just not for Senna. Look to Lucian if you wanna try some tower dive hijinx, but definitely not here.
Taric
Don't do this to yourself please. You aren't gonna be near the fight. He's gonna get poked down. Look at literally any other pick.
Senna ADC S12 Build
Build Guide By Stella_Umbra
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