Not Updated For Current Season
The masteries shown here are not yet updated for the current season, the guide author needs to set up the new masteries. As such, they will be different than the masteries you see in-game.
Threats to Vayne with this build
|Garen||Laning against Garen is really easy. Try to get to the lane before him, killing the first melee minion to gain advantage. Later on don't let him get closer to minions by denying him the farm. When he gets close to a minion to last-hit it, shoot him in the face with your crossbow.(AA+Q+AA/E) I highly recommend poking a lot when your cannon minion is about to die, because most of the players value it as important and will probably go for it. As soon as you notice he's charging on you with his Q, basic attack him, Q back - hit him, and use E as soon as you can to push him back and avoid damage(remember that if you use your E at the exactly same time he hits you with Q, your spell still triggers and knocks him back despite the silence).|