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Shielding and Zone control. Lux can innately shield some of Karthus' aoe damage away. She can also attempt to snipe Karthus pre/during fight and have him die a safe distance away from you and your long range.
Ryze
Ryze is very weak against long ranged ap mages. Keep your distance, and if Ryze ever wants to start walking towards you, you can combo him with Q+E (autos between) and chunk him, and shield his damage.
Malzahar
Since Malzahar's skills are all animated before the hit you can predict his area of damage and try to avoid it. Harase with e and q and avoid getting under his ulti by not getting to close to him because this leads to death
Heimerdinger
No Turrets, No Problems. Lux can clear turrets instantly and safely with her long range reducing Heimer's pushing ability and making him consume mana. Alone Heimerdinger is an easy kill.
Azir
Azir got big range dont go too close. try to combo him w/t Q/E/R if u miss Q go back & use W.
Akali
keep your stun(Q) ready if akali has her Ultimate ready. if she jumps to you activate your shield(W) and stun her. after she gets stunned walk away and poke her with the E. if shes low enough stun and finish her with your ultimate.
Syndra
Syndra will destroy you if she gets close but she has very little in the way of getting to you. Stick to poking her at max range with E until she is getting low enough that she will back off, that range her stun even if it lands won't do much against you
Talon
In order, max out R/E/W, and harass from distance. Max Q last to use if you live through his E/W/Q combo. To kill, throw out a Q and E at the same time, if Q lands, use your R, then you can auto attack to activate your passive while you are silenced.
Ziggs
As you would do with any champion, try to poke Ziggs from maximum range using your E. Although, do not attempt to trigger your passive when he has his passive up.
Xerath
Save your bind for when you see him starting to channel his Q or ultimate for a much easier hit
Ahri
Although her mobility can be an issue for a champ reliant on skillshots, Ahri's like to open with their dash aimed at you to get an easier Charm. You can use this predictability to QER her as she jumps in as she is just as soft as you are.
Yasuo
Easy match up if you use your range to your advantage. Use Lux's range with her auto-attacks to force Yasuo to use his barrier passive and make it dissappear. As he builds it back up, harass away with Q/E/R combo with auto attacks in between. No problem!
Veigar
Zone with e, force him on tower. be mindful of ganks because his stun is a powerful tool.
Ekko
Wait for him to use his E then combo Q/E/R & hes done. Also be careful for his W if he stun you you're done.
Orianna
You'll struggle to kill a good ori until you hit 6. She will win in trades if you let her get in range to zone with your E and DONT go for passive procs on her. At 6 catch her with a Q and combo her be careful when getting the ignite in if you're low
Morgana
Be careful & try to avoid her stuns. Use E, so she can use her shield. When the shield is gone Simply Q/R if u got rdy E - Q/E/R :)
Diana
Don't let her farm, play agressive before level 6, but be carefull from he jungler, try to take a kill before level 6, and spam her!
Kassadin
This guy is ****. U can defend urself from his Q with W. Wait for him to use Q & When shield from his Q is gone use Q/E/R. Play defencive vs him.
LeBlanc
You can counter LB with lux by harassing her with your long ranged poke and if she goes in just bind her and poke but if shes low enough you can use your entire combo on her.
Zed
Hard match-up. In order, max R/E/W/Q. Harass with E and use W when you get caught with Zed's Death Mark. Learn to activate R instantly if you know your Q will connect to give Zed as little time as possible to teleport away. Don't give up! You can get Barrier for his ult.
Katarina
Early game, farm safely and snare when you can when jungler ganks. Once you have your items, make sure to deal dmg at a distance by doing your Q+E combo repeatedly until she is low and finish her off with Final Spark. It helps to get Zhonya's if she ults
Fizz
In order, max R/E/W/Q. Harass with E. For a kill, if your Q lands, instantly use R to activate your passive, then E/W auto-attack. Many people will not see the immediate R coming and will only activate Trickster after Lux's R. Wait, then E/W auto-attack.
Nidalee
Try to avoid her Q if Q hit u she can izi kill u . Stay under turret & farm.
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