11.13: Huge patch. Luden's price is reduced by 200 gold and Lich Bane now has 5 more AP. Everything this build could ask for.

8/7/2021: Updated build, replaced Mejai's Soulstealer with Nashor's Tooth.

Twisted Fate has one of, if not the most strongest burst from a single auto attack. W has an impressive 90% AP ratio, E has 50%, Lich Bane has 40%, Nashor's Tooth has 20%, Luden's Tempest has 10% and Aery/Predator have 10%. That adds up to a total of 220% AP ratio on a single auto attack. My goal with this guide is to deal a true oneshot, and that is the story behind Magnificently Construct Twisted Fate.

You get brownie points if you use The Magnificent Twisted Fate with this build.

Predator was the original plan. Activate your shoes, run someone down and oneshot the ADC. An issue came up though when I came to 5 items. I could oneshot Kai'sa with ease, but I was just a tad bit short on the other players. Selling boots for Void Staff would have solved an issue, but alas, I was left with a useless keystone. Sadly, Predator is the only rune that can truly be used for a oneshot. Summon Aery was the closest I could find.

The reason Predator was so perfect was because Predator did damage in the same tick as the auto attack. Aery is impossible to dodge and it has the exact same AP scaling as Predator so it is technically still a oneshot, but Aery is dealt in a short moment after the auto.

TL;DR Aery is way more practical for our purposes, Predator is the only true oneshot rune.

The items are self explanatory. We want a mix of pure AP and pure damage. The only viable combination of items here is Luden's Tempest, Lich Bane, Seraph's Embrace, Rabadon's Deathcap, Nashor's Tooth and Void Staff. Luden's is the only viable mythic due to the Magic Penetration we get because our build does not buy boots if we go Aery. Night harvester is just an awful alternative because it lacks everything we needs for our build. Now we have a perfect split between raw AP items and raw burst and this is the most damage we can get out from items.

Until you've finished your first two items you're literally a wet tissue. Your damage is extremely subpar, your best best is perma farming. Cull helps immensely with that. If you go for Aery you can also poke incredibly well with Q, especially if you max it first. You don't have a lot of all in potential but your poke is very annoying. With Cull and Loaded Dice you will reach your powerspikes way way faster.

Basically you want to permafarm, scale and never roam for kills unless it's a done deal.

Congrats, you're full build! You've overcome all the hardships of early and mid game, you've made sure not to feed the enemy laner, you have farmed as well as you can and now you're at the peak of your champion's power. With the power of math and magnificence you can now unleash your full power. This is a glass cannon build and you should treat it as such. If you're badly positioned you will die. You will take someone with you, but you will die. You need to play as safe as possible and only cast your ultimate when it's guaranteed you will not be oneshot the second you teleport. But now, if anyone ever walks up to you they will die, no questions asked. Now you just have to go ham and try to end quick, because even though you're very strong, a death in lategame can cost the entire game. Treat this part of the game with the care it requires. Good luck and have fun.

Once you have your Lich Bane it's rarely worth it to pick gold card. At this point it's more worth to go for a oneshot.
If someone tries to all in you in lane, you can return decent damage while walking away.
Always always always try to have your E fully stacked after clearing a wave.
Try to utilize your ultimate as much as possible so you can make full use of Sudden Impact.
Never get hit by any cc at any cost. You're dead.
NEVER, and I do mean never attack click move with your blue card. I can't even begin to express how many times I've died because I accidentally hit a minion with my blue card.

I know this build is very suboptimal. That's the point. This guide is written to push the champion to it's limits. I hope you have fun playing my build and you don't get flamed for it. Most important part is to have fun!