WARNING: These masteries are still using the old tree and have not been updated to the new tree by the guide author. As such, they will be different than the masteries you see in-game.
Singed descended from a long line of Zaun's revered chemists. Even in his youth, his talent for concocting potions far outstripped that of his peers, and he quickly distinguished himself from his less extraordinary chemist compatriots. It came as no surprise to anyone when he was selected for apprenticeship by the infamous Warwick, master apothecary on a lucrative retainer with the Noxian military during their campaign against Ionia. Within Warwick's laboratories, Singed toiled without end, rapidly absorbing every detail of his predecessor's deadly craft. Singed had little concern for the death and destruction that was the fruit of his labors. By the time the curse of lycanthropy descended to claim his master, Singed was poised and eager to make the transition from workhorse to innovator; he was ready to share his genius by bringing a new brand of suffering to the Ionian front. His zeal for progress was unquenchable, and when suitable test subjects proved to be in short supply, the eager chemist was often thought to turn his volatile mixtures on his own flesh.
Pros / Cons
Now I want to tell you a little bit about the Pro´s and Con´s by Singed.
Pro´s
Very Tanky
Nice Damage
Fastest man
Zoning slow
Con´s
Low range
Early game low damage
No stun
Starting Stats
Health 1842
Mana 1025
Speed 320
Armor 81
Magic Resist 30
Critical Chance 0%
Health Per 5 Sec 17
Mana Per 5 Sec 16.5
Range 125
What do we need?
Speed - YES!
Tanky - YES!
What we get from our mastery? Both!
That's why our great mastery 1/21/8.
It is keeping a lot of damage, and you run 5% faster.
Items
Early Items
Philosopher's Stone we use as HP5 and MP5 at the beginning of the game are very useful. And we get more Gold and after 26 minutes it has paid for itself.
Boots of Swiftness We use these boots so we always have a little bit faster than any other.
Rod of Ages The coreitem for Singed. It gives hp and mana, and in addition give live again with Empowered Bulwark even more. Besides these, it brings a lot of what our ap who increases you Dmg.
I prefer teleport, so if you go back to base u can port back into fight. And You are more mobily.
Farming
To farm with singed is the simplest of the world we activate Poison Trail and run to the minions. So we can afford more expensive items because we constantly kill large quantities of minions and get a nice farm.
List of terms
AA = Auto-attack (Basic Attacks)
AD = Attack Damage
AP = Ability Power
AS = Attack Speed
AoE = Area of Effect
CC = Crowd Control (Stun, fear, slow, snare, etc)
CDR = Cooldown Reduction
DoT = Damage over Time
ELO = Elo rating (Rating system designed by Arpad Elo that is now used in gaming communities worldwide)
FB = First Blood
GP10 = Gold Per 10
HP = Health
LS = Life Steal
MD = Magic Damage
MP = Mana
MR = Magic Resistance
MS = Movement Speed
OOM = Out of Mana
SV = Spell Vamp
DPS = Damage Per Second; also: Strong Auto-attacker
MDPS = Magical Damage Per Second; also:Strong spells; casters
MP5 = Mana Regeneration per 5 seconds
HP5 = Health Regeneration per 5 seconds
ArPen = Armor Penetration
MPen = Magic Penetration
Summary
And now last but not least a great song to listen while you destroy the enemy.
Build Guide
Discussion (2)
Greater Mark of Magic Penetration
Greater Seal of Armor
Greater Glyph of Scaling Magic Resist
Greater Quintessence of Movement Speed
Philosopher's Stone we use as HP5 and MP5 at the beginning of the game are very useful. And we get more Gold and after 26 minutes it has paid for itself.
Boots of Swiftness We use these boots so we always have a little bit faster than any other.
Catalyst the Protector A very good item for Singed because it gives hp and mana, and additional 
Rod of Ages The coreitem for Singed. It gives hp and mana, and in addition give live again with 
Force of Nature
Frozen Heart
