Please read the whole build before you decide to rate it.

6/3/2011
-changed item purchase order
-changed item descriptions
-changed skill descriptions
-Changed masteries to a 21/9/0 setup

Now, before I start into my build, I want to explain why I didn't choose an Ability Power build or an Attack Damage build.

AP builds for Vayne are focused around your skill Tumble. At first this seems alright, but as you progress through a game you will find yourself weak and unable to do much damage because it’s not your skills that are your main damage source, it's your auto attack.

AD builds are a lot better than AP builds. They focus on damage output but still lack the attack speed necessary to quickly deal out damage to an enemy.

My build is focused on the skill Silver Bolts. This is your main skill, no if, ands, or buts. This skill provides you with a passive that will destroy your enemy’s health. Every third consecutive hit on an enemy or minion will deal additional damage and will deal true damage equal to a set percent of the targets maximum health. So every third hit you're dealing out a lot of damage. But in order to get that third hit off quickly you need to have a high attack speed. Which leads us to my Attack Speed build. This build may not seem like as good of a build as an attack damage build, but when u try it out and get the first three items, you will notice how good it is.

With a high Attack Speed you will be greatly increases your damage output by utilizing your Silver Bolts skill. What's especially great about Silver Bolts not the additional damage it brings to the table, but the ‘% of health’ damage that it lets you dish out. This is especially useful against tanks, and paired with Madred's Bloodrazor, the amount of damage you are doing to any enemy will down them in no time (I'll explain more about Madred's Bloodrazor in the Items section of the guide). With Vayne you will quickly find out that your auto attack is your main damage dealer, and a really good one at that. Without using any skills you can take down an enemy in no time, and with your ultimate Final Hour they will die even faster.

First grab Boots of Speed and 3 health potion and go to your lane. Seeing as Vayne is very slow at first, these help you to be faster and be able to buy 3 potions with the extra money that you have left over, allowing you to heal and stay in your lane longer so that you have more time to farm.

Then get berserker’s greaves Berserker’s Greaves which help with attack speed and movement speed.

Next, take Zeal. You get attack speed, crit chance, and movement speed, all in one item. This helps Vayne out tremendously at early levels. Build your Zeal into a Phantom Dancer, which gives you even more attack peed, crit chance, and movement speed.

Now it’s time for . This item was made for Vayne. It gives you attack damage, attack speed, armor (which is very helpful since Vayne is squishy), and a passive that wrecks your enemies. Combine Silver Bolts, madred’s bloodrazor Madred’s Bloodrazor, and Attack Speed and you get a wicked amount of damage output, especially on your third hit. Your Silver Bolts skill deals a percent of the targets health as true damage (8% when maxed), and Madred’s Bloodrazor deals 4% of the enemy’s health as damage. That’s 12% of their health as damage, plus all your other normal damage output. That’s a pretty good amount of damage each hit, and on third hits you see their health drop a ton.

These three items are your core build. With just these items you will be a very formidable force. Oh, and you still have three more slots open for any other items you want.

Next is Wit's End which gives you 40% more attack speed and 42 bonus magic damage per hit, which can greatly help against characters that don't have a lot of Magic Resist. It also stacks magic resistance while you kill things, which helps when facing casters since Vayne is weak against magic attacks.

Black Cleaver is next. If you thought you were dealing out great damage before you got this item, you will be in awe of your damage after you buy it. Not only does it give you more Attack Speed, it also REDUCES YOUR ENEMIES ARMOR. What?! So now not only are you dealing insane damage, you’re also lowering their armor to deal even MORE damage.

Now for lifesteal, which is why I chose Vampiric Scepter as the next item. After you choose your sixth item you can turn the Vampiric Scepter into The Bloodthirster.

Your final item is The Bloodthirster. It gives you 60 Attack Damage and 15% Lifesteal. Its passives i that you gain an additional 1 Physical Damage and 0.25% Lifesteal per kill. Maximum of +40 Damage and 10% Lifesteal. Bonuses are lost upon death.

Vayne is a very squishy character, so going out and initiating the fight with your enemies is definitely NOT the right thing to do. Harassing is fine, and 1v1 is fine, but in team fights, you have to stay behind your teammates and wait until the right moment to strike, which is usually when an enemy gets separated from his teammates or the enemy you’re going for is at half health or less.

Stay mobile and use Tumble to dodge around and avoid enemies and their attacks. Always look for last hits on minions so that you get the most amount of money you can. The items you’re trying to buy are expensive, so keep farming.

BE CAUTIOUS. Never rush into a fight or at an enemy after the laning phase without a teammate. If you do, you will usually die because there is a second enemy waiting for you that you can’t see. During the laning phase it’s ok to be a little more aggressive, but don’t try to push your luck.

However, there is always an exception to the rule. Vayne is a GREAT chaser. If an enemy has low health and is running away, chase them. As long as they don’t have any teammates around that are a threat to you, then by all means, chase that sucker down and end him.

Max out Silver Bolts, then Tumble, then Condemn. Take your ultimate whenever you can, which is at levels 6, 11, and 16.

Passive - Night Hunter: Vayne ruthlessly hunts evil-doers. She gains bonus Movement Speed when moving toward nearby enemy champions.

Tumble – Vayne tumbles, maneuvering to carefully place her next shot. She rolls toward the cursor and her next attack deals bonus damage.

Silver Bolts – Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target’s maximum Health as bonus true damage. (Max damage vs. Monsters is capped)

Condemn – Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, dealing damage and knocking them back. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.
This is actually a really great move. Whenever you see an opportunity to pin an enemy to any terrain, do it. They will be stunned and you will get some free shots off on them and do a lot of damage before they are able to recover.

Final Hour – Readying herself for an epic confrontation, Vayne gains increased Attack Damage, stealth during Tumble, and quadruple the bonus Movement Speed from Night Hunter.

Vayne is the ultimate damage dealer. With a lot of Attack Speed she really pours out the damage and kills enemies quickly. She is also a GREAT chaser. She is a really fun character to play. I hope you enjoyed the guide and were able to learn something from it. Leave a rating or comment, constructive criticism is always appreciated, thanks :D