Hey All.
This is my first guide and i hope you all like it :)

please Read the guide before trying it out, and please try it more than once or twice before rating ;)

For marks i have chosen Greater Mark of Desolation for some extra damage

For seals i have chosen Greater Seal of Attack Speed for some attack speed, you can use Greater Seal of Scaling Attack Damage for even more attack dmg, but i like attack speed best.

For Glyph i use Greater Glyph of Magic Resist for some magic resist, and again you can take Greater Glyph of Scaling Attack Damage for more dmg

For Quintessences i use Greater Quintessence of Desolation. You can also use Greater Quintessence of Movement Speed to get the extra boost of movementspeed.

For Masteries i have chosen a basic 21-0-9 for the dmg in offence and hp/mana regen, more xp and longer buff durations in utility. Remember to take the improved vertion of your summoner skill unless you use ignite or flash, because the ap from Burning Embers is totaly useless on Vayne, and Blink of an Eye can you only take if you go into utility, wich you can but i would not recomend it.

The first build is the one i recomend to people that is new to Vayne and dont know her limits. It focuses on survivability and have a mutch lower dmg output, but should be enuogh to get you the kills you need while you stay alive

The second build i have made is focused on high dmg and little survivability, so remember to buy Elixir of Fortitude if you have the money. This will make you hated if you play right.

Items
Now it begins to get a little interesting :)

Build 1.
I start with Doran's Blade because i think that it's a great item because of the health, dmg and lifesteal :)
Then I get my Boots and rush my B. F. Sword.
Then I pick up my Berserker's Greaves and Wriggle's Lantern, and now you a probably like "Whaaaat!? why would you buy lantern?" and i will answer your question with
"yea yea i know it probably isnt the best pick to Vayne, but it's a so damn good item, you will be able to farm the hell out of the lanes and jungle, and you will not even take the slightest dmg even if you run into a champion while farming".
Now I upgrade my B. F. Sword into an Infinity Edge to get some nice crits, and a Cloak and Dagger for the tenacety because cc is just a pain. Now the game should be near the end, but if not you should go for Bloodthirster and a Frozen Mallet if you dont have anything else you want or can spend your money on.



Build 2.
Again I start with Doran's Blade
Then i go on to Sheen by buying Sapphire Crystal first, because the ap from tome doesn't help us in any way. For boots you would pick what fits best against the enemy team but most of the time i pick Berserker's Greaves for the attack speed boost.
The next item is Trinity Force. buying Phage first because of the health boost (wich is mutch needed) and the slow for ganking.
My next item will be Cloak and Dagger or if the enemy team doesnt have any cc i would take Phantom Dancer, then we get to the Infinity Edge. This item will boost your dmg to the insane, and with Bloodthirster as the next item you will be allmost unstoppable :)
The las item is realy up to you (if the game last that long) i just buy Elixir of Fortitude and Elixir of Agility for the rest of the game, until i can buy Madred's Bloodrazor.

For summoner spells i use Flash and Exhaust or Flash and Ghost.
You can take Ignite to

I will recomend that you take atleast one of eather Flash or Ghost as an escape skill, cause you have a low base movement speed and tumble doesn't work thrugh walls so its not good to escape with.

Night Hunter

This is your pasive and what makes you the chaser you are, this gives you 40 when moveing towards an enemy champion

Tumble

This is your harasing skill. in the begining you want to tumble to the side and hit the enemy championt, later you want to combine this with Condemn for a good stun

Silver Bolts

This skill is great to tanks because of the true dmg, and even greater for the squshie Veigar on the enemy team :)

Condemn

This is your stun/knockback ability. You want to hit people into walls with this if possible, if not be carefull not to shoot your kill away from you

Final Hour

This is your ultimate, it improves your pasive, give you more dmg and a little short stealth on your tumble. This is basicly what makes you the feared assassin you are :)

The skill sequence depends on your playstyle, but the way i prioritise my skills in most games is like this :

Final Hour
Tumble
Silver Bolts
Condemn

Now with the first build you probably wont be able to carry that well, so with that you are the ranged dps that stand as far away as possible while still being able to autoatack.

With the second build you are the hard carry your job is to kill the enemy squshies and carry and get away without dying, and remember that tradeing you for an enemy is never good!

-Pros

-Good ganker
-Great chaser
-Good dmg output
-Able to take any lane
-Exelent harase

Cons

-Cant solo lane 1v2
-Realy weak early game
-Not the best farmer in the game
-Low movementspeed will make you go nuts when excapeing

So this is how i play Vayne and i hope i have been a help to all of those who want to play Vayne and have some fun :)

and plzz tell me if there is somthing you want me to try or somthing you think could be better :)