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One of the easiest to harrass in lane. If she gets any ideas, cancel her Q with your own. Keep your distance when she has Stun up, and when it's not there--abuse her. You can predict and completely dodge Tibbers with R easily. Build sorc boots if she builds any MR.
Teemo
Use your Q to avoid damage from his poison and Blind dart. You can easily avoid his shrooms with your R. He has very little escape potential, and he deals next to no damage when building AP.
Ekko
During Laning phase, Ekko has the potential to be a pest due to his passive and dash, but due to him only dealing Magic damage, you can easily win trades and completely nullify his damage when maxing Q. You can easily take an offensive against him very early on and once you get Rift-walk, he will find it very hard to kill you.
Lissandra
Due to her CC, ultimate, and escape potential, she wont be an easy opponent. You can beat her in trades, but once she has ultimate, you'll want to have merc treads and some AP by then.
Yasuo
Some may think Yasuo counters Kassadin, however, they both have advantages over the other. Yasuo's wind wall can stop Kass Q, but not his E. Kassadin can still escape with his passive's lack of unit collision, and Kass can dodge Yasuo's Q with relative ease due to this. Once you have some Armor and AP, Yasuo's chance of victory against you will start to slip--even if he gets a Maw or Phantom.
Zed
Rush Armguard from the start. Get Sorc boots if he grabs Maw. Hourglass is essential in this match-up, as it can completely avoid Zed's ult all-together. This fight isn't too hard, but it can be very dangerous if you go with a RoA rush before ever considering Armguard.
Orianna
Due to her range, damage, and CC, she is not a favorable match-up for Kassadin. She can shield against his Q, but you can do the same. This is roughly an even fight, but the tip falls to Orianna's favor due to superior range and wave-clear.
Ezreal
Here come the hard match-ups... Ezreal mids are a pain for Kassadin, and you can not punish him due to his mobility and wave-clear potential. Once you hit 6, it gets easier, but avoid this match-up all together unless you can easily avoid his Q/W/E/R. Tough fight.
Lucian
You want to avoid this match-up at all costs. Due to Lucian's kit, he can easily poke down Kassadin and bait his R and avoid it with his dash. He has very little to worry about you.
Katarina
Kat starts out as an easy opponent, but once she gets her Gunblade, you must take the might more seriously. Due to sustain, mobility, and damage, Kat can become a threat to kassadin, but due to your R and Q, you can easily stop Kat's ultimate as long as you save them for it.
Pantheon
While a non-meta pick due to how easily he falls off, Pantheon completely counters kassadin due to his passive and Q. During lane, you will experience hell, but as long as you build Armor and survive for late game, Pantheon is going to fall off.
Aurelion Sol
This is a joke. Your Q counters his Passive/W and resets them. Your R makes it impossible for Sol to even hit you with his Q and W. You can also catch him while he is trying to escape with E using your Q. He stands VERY little chance against Kassadin.
Azir
Due to ranged poke, this will be a very annoying fight early on, but once you hit 6 and don't feed him kills, you'll be able to catch him out once he wastes his Q or R. Focus on beating him in the late game, as he has the upper-hand in lane and pre-6.
Heimerdinger
This is just annoying. You can burst him, but he can do the same--but with CC. you have mobility, but he has stuns and range. Play passive until you can burst him down with R+W+Q+E.
Jayce
AD, ranged, and has bonus mobility + cc. He's not a favorable match-up for Kassadin, but you can still win once you hit 6. I don't recommend this match-up, though.
Vladimir
due to his sustain and instant damage with his Q, he's a little tough to counter with spell-shield. However, once you start building Morello, he is as good as dead.
Swain
His snare can ruin you, but otherwise, as long as you have the damage and Morello, he is practically useless against you.
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