I only properly played 3, but part of what made 3 for me was being able to experience it in co-op with a friend. Singleplayer games just don't do it for me anymore. :( Aside from Mass Effect 2-3 which I'm currently addicted to. The last singleplayer games I really enjoyed before that were Fable 2 and 3.

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If you haven't seen the Blue Team trailer, watch it and be amazed.