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LoL Champion Build Guides: Cassiopeia

Cassiopeia RP Cost 880 Cassiopeia BE Cost4800
Pick 78%
Win 52%
Pick 11%
Win 54%
Pick 11%
Win 51%
Wishlist

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends Patch 10.21. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S10 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!


Season 10 Guides
LoL Champion Cassiopeia Build Guide

[10.21 Rezone's Indepth Midlane Cassiopeia SEASON 10!

Guide by RezoneVerified updated October 18, 2020
  • 10.21
  • In-depth
Votes: 126
Views: 415,196
LoL Champion Cassiopeia Build Guide

[10.21] Raen's Cassiopeia (°,,°) Tips & Build

Guide by Raen updated October 19, 2020
  • 10.21
  • Stream
Votes: 39
Views: 88,594
LoL Champion Cassiopeia Build Guide

Yeager's Master Cassiopeia Guide

Guide by Yeager updated September 30, 2020
  • 10.20
  • In-depth
Votes: 885
Views: 2,438,429
Season 10 Builds
LoL Champion Cassiopeia Build Guide

[10.20] - Annihilate Your Game With Cassiopeia

Build by LethalCassiopeia updated October 1, 2020
  • 10.20
Votes: 13
Views: 18,473
LoL Champion Cassiopeia Build Guide

Cassiopeia Begginner guide/ All matchups

Build by Guest updated October 9, 2020
  • 10.20
New Build
Views: 340
LoL Champion Cassiopeia Build Guide

Snek (Mid)

Build by ObserverOfTime updated September 30, 2020
  • 10.20
Rating Pending
Views: 566
LoL Champion Cassiopeia Build Guide

Cassiopeia Jesuscirraptor JG

Build by Jesuscirraptor updated September 10, 2020
  • 10.18
Rating Pending
Views: 3,909
LoL Champion Cassiopeia Build Guide

Cass yo pya [10.17]

Build by nusc updated August 27, 2020
  • 10.17
Rating Pending
Views: 646
LoL Champion Cassiopeia Build Guide

[10.17] The holy and blessed Cassiopeia guide!

Build by SnakeOnRiver updated August 26, 2020
  • 10.17
Rating Pending
Views: 1,423
LoL Champion Cassiopeia Build Guide

yer's Recommended botlane

Build by yers updated August 25, 2020
  • 10.17
Rating Pending
Views: 2,782
LoL Champion Cassiopeia Build Guide

Jwjsndndjdkdmdneiskfjflsdlpdndnxndnjdkrkrlelpfpfpfpcl

Build by zakAvalus updated August 31, 2020
  • 10.17
Rating Pending
Views: 735
LoL Champion Cassiopeia Build Guide

Cassiopeia Jesuscirraptor SUP

Build by Jesuscirraptor updated August 11, 2020
  • 10.16
Rating Pending
Views: 5,349
LoL Champion Cassiopeia Build Guide

The tankiopea

Build by SwrdMaster updated August 9, 2020
  • 10.16
Rating Pending
Views: 2,129
LoL Champion Cassiopeia Build Guide

RRRRRANK 1 CASSIOPIA(Pun1sher)

Build by Guest updated August 15, 2020
  • 10.16
Rating Pending
Views: 739
LoL Champion Cassiopeia Build Guide

cassiopiea jungle

Build by Guest updated July 27, 2020
  • 10.15
Rating Pending
Views: 1,133
LoL Champion Cassiopeia Build Guide

Cass Late game Carry

Build by smokiie updated July 21, 2020
  • 10.14
Rating Pending
Views: 18,747
LoL Champion Cassiopeia Build Guide

Cassiopeia Mid (Conq)

Build by SaimonsJuniorLP updated July 14, 2020
  • 10.14
Rating Pending
Views: 928
LoL Champion Cassiopeia Build Guide

God Tier Cassiopeia

Build by ROFLMAOXD updated July 20, 2020
  • 10.14
Rating Pending
Views: 3,365
LoL Champion Cassiopeia Build Guide

best cassio EUW insane stomping lane

Build by Erolle updated July 18, 2020
  • 10.14
Rating Pending
Views: 453
LoL Champion Cassiopeia Build Guide

Cassiopeia

Build by Majkyy updated July 18, 2020
  • 10.14
Rating Pending
Views: 644
1 2 3 4 5 6 7 8 18 29

Cassiopeia Build Stats

Patch 10.21: 283993 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 51%

Win Rate 4133 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 50%

Win Rate 1706 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 55%

Win Rate 836 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 10750 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 51%

Win Rate 5085 Games

Flash Ignite

Third Best

Cassiopeia's 3rd Best Summoner Spells 49%

Win Rate 2060 Games

Flash Barrier

Cassiopeia's Starters

Cassiopeia's Best Starter Items 51%

Win Rate 22355 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 52%

Win Rate 2322 Games

Corrupting Potion

Third Best

Cassiopeia's 3rd Best Starter Items 53%

Win Rate 2038 Games

Sapphire Crystal Refillable Potion

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 14439 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 54%

Win Rate 5951 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 1798 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 68%

Win Rate 2330 Games

  • 1
  • 2
  • 3
Patch 10.21: 284001 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 52%

Win Rate 813 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 55%

Win Rate 164 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 55%

Win Rate 197 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 50%

Win Rate 1241 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 56%

Win Rate 580 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 51%

Win Rate 357 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 51%

Win Rate 2195 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 56%

Win Rate 238 Games

Sapphire Crystal Refillable Potion

Third Best

Cassiopeia's 3rd Best Starter Items 48%

Win Rate 148 Games

Corrupting Potion

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 1438 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 53%

Win Rate 997 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 58%

Win Rate 191 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 67%

Win Rate 105 Games

  • 1
Patch 10.21: 283997 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 58%

Win Rate 101 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 57%

Win Rate 56 Games

Sorcery
LoL Path: Sorcery
LoL Rune: Phase Rush
Phase Rush
LoL Rune: Manaflow Band
Manaflow Band
LoL Rune: Transcendence
Transcendence
LoL Rune: Gathering Storm
Gathering Storm

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 57%

Win Rate 72 Games

Sorcery
LoL Path: Sorcery
LoL Rune: Phase Rush
Phase Rush
LoL Rune: Manaflow Band
Manaflow Band
LoL Rune: Transcendence
Transcendence
LoL Rune: Scorch
Scorch

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 49%

Win Rate 2224 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 56%

Win Rate 94 Games

Flash Barrier

Third Best

Cassiopeia's 3rd Best Summoner Spells 56%

Win Rate 84 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 50%

Win Rate 3527 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 54%

Win Rate 443 Games

Sapphire Crystal Refillable Potion

Third Best

Cassiopeia's 3rd Best Starter Items 53%

Win Rate 477 Games

Corrupting Potion

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 1882 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 53%

Win Rate 655 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 51%

Win Rate 237 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 77%

Win Rate 160 Games

  • 1
  • 2

Cassiopeia Skins

Cassiopeia's Abilities

Ability Range Cost Cooldown
Cassiopeia's Serpentine Grace
Serpentine Grace Cassiopeia's Passive Cassiopeia's Passive
Self
Cassiopeia's Passive
Cassiopeia's Passive
Cassiopeia gains 4 Movement Speed per level. Cassiopeia cannot purchase Boots items.
Q
Cassiopeia's Noxious Blast
Noxious Blast Cassiopeia's Q Ability
850
50 / 60 / 70 / 80 / 90
3.5
Cassiopeia blasts an area with a delayed high damaging poison, dealing 75 / 110 / 145 / 180 / 215 (+90% of ability power) magic damage over 3 seconds and granting her 30 / 35 / 40 / 45 / 50% movement speed which decays over 3 seconds if she hits a champion.
W
Cassiopeia's Miasma
Miasma Cassiopeia's W Ability
700
70 / 80 / 90 / 100 / 110
24 / 22 / 20 / 18 / 16
Cassiopeia spews venom in an arc in front of her, leaving toxic clouds for 5 seconds. Enemies in the cloud take 20 / 25 / 30 / 35 / 40 (+15% of ability power) magic damage per second, are slowed by 40 / 50 / 60 / 70 / 80% (decays over the duration) and are grounded, prohibiting the use of movement abilities.
E
Cassiopeia's Twin Fang
Twin Fang Cassiopeia's E Ability
700
50
0.75
Cassiopeia deals 48 (+4x champion level) (+10% of ability power) magic damage to her target.

If the target is poisoned, Twin Fang deals 10 / 30 / 50 / 70 / 90 (+60% of ability power) bonus magic damage and restores 12 / 14 / 16 / 18 / 20% of Cassiopeia's ability power to her as health. This heal is 75% less effective against minions and small monsters.

If Twin Fang kills a unit, its mana cost is refunded.
R
Cassiopeia's Petrifying Gaze
Petrifying Gaze Cassiopeia's Ultimate (R) Ability
825
100
120 / 100 / 80 / 80 / 80
Cassiopeia releases a swirl of magical energy from her eyes, dealing 150 / 250 / 350 (+50% of ability power) magic damage to all enemies in front of her. Enemies facing her are stunned for 2 seconds, while enemies facing away are slowed by 40% for the same duration.

Questions About Cassiopeia

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