Click to open network menu
Join or Log In
Mobafire logo

Join the leading League of Legends community. Create and share Champion Guides and Builds.

Create an MFN Account






Or

Cassiopeia Build Guides, Runes and Items

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends S12 Patch 12.15. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S12 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!

Season 12 Guides // Patch 12.15 & Patch 12.14
9.8
352
Votes
19
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[ NEW SEASON 12 - 12.15 UPDATED!! ] CASSIOPEIA - The POISON Queen of Midlane ☠

Guide by RezoneVerified updated August 11, 2022
  • In-depth
9.5
279
Votes
16
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Hyrav's Challenger Rank 1 Cassiopeia Guide

Guide by Hyrav updated August 2, 2022
  • In-depth
8.9
56
Votes
8
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Raen's Cassiopeia (°,,°) Tips & Build

Guide by Raen updated August 12, 2022
8.1
17
Votes
4
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[12.15] Zethal's Grandmaster Cassiopeia Guide - What To Build

Guide by Zethal_Na updated August 12, 2022
  • In-depth
New Guide
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia Build Guide Season 12 (low ELO)

Guide by Mvrshy updated August 13, 2022
  • In-depth
Season 12 Guides // Other Patches
10
1183
Votes
50
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Yeager's Master Cassiopeia Guide

Guide by Yeager updated April 20, 2022
  • In-depth
9.3
19
Votes
1
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

yer's Recommended botlane [preseason 12 update]

Guide by yers updated November 22, 2021
  • In-depth
9.2
45
Votes
4
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[S12] Ultimate MASTERS+ Cassiopeia || Build Exodia and 1v9

Guide by xLessThanThree updated November 30, 2021
  • In-depth
8.5
8
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Huntervault's Gargoyle Cassiopeia Guide

Guide by Huntervault updated January 24, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Anithero Cassiopeia Guide

Guide by Flipps updated April 9, 2022
  • Off-Meta
5.6
2
Votes
6
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Casseiessippi

Guide by BowlOfSoup updated January 20, 2022
  • Off-Meta
Season 12 Builds // Other Patches
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassio

Build by Kyster Draven updated February 10, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia mid-late powerspike

Build by Guest updated January 26, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Depressed. Cassiopeia.

Build by DepressedCassio updated February 5, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia tank

Build by Guest updated July 11, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassio

Build by Guest updated February 17, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

House of Menaces: Cassiopeia

Build by junioralchemy updated November 29, 2021
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia

Build by HiramBattle updated November 27, 2021
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

c

Build by Guest updated November 23, 2021
Season 11 Guides
9.7
20
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

ReYkoTheLord's Challenger Cassiopeia Guide 11.8

Guide by ReYkoTheLord updated April 27, 2021
1 2 3 4 5 6 7 8 19 31
Create a Cassiopeia Build Guide Create a Cassiopeia Build Guide
Craft your own guide
Get Started

Cassiopeia Build & Runes

If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 12.15. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!

Patch 12.14: 438954 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 52%

Win Rate 2758 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Second Best

Cassiopeia's 2nd Best Runes 66%

Win Rate 53 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Third Best

Cassiopeia's 3rd Best Runes 61%

Win Rate 75 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 4982 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 53%

Win Rate 4035 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 55%

Win Rate 1374 Games

Flash Barrier

Cassiopeia's Starters

Cassiopeia's Best Starter Items 53%

Win Rate 10264 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 50%

Win Rate 7903 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 54%

Win Rate 4472 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 55%

Win Rate 1582 Games

Oracle Lens
Don’t forget
to Buy Wards
Patch 12.14: 438954 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 55%

Win Rate 227 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Second Best

Cassiopeia's 2nd Best Runes 52%

Win Rate 266 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Third Best

Cassiopeia's 3rd Best Runes 48%

Win Rate 77 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 56%

Win Rate 617 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 50%

Win Rate 1097 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 55%

Win Rate 232 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 53%

Win Rate 1798 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 55%

Win Rate 87 Games

Corrupting Potion

Third Best

Cassiopeia's 3rd Best Starter Items 51%

Win Rate 339 Games

Doran's Ring Health Potion

Trinket

Cassiopeia's Best Trinket 52%

Win Rate 1280 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 54%

Win Rate 717 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 336 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 68%

Win Rate 115 Games

  • 1
  • 2
Patch 11.20: 494917 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 62%

Win Rate 55 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 53%

Win Rate 169 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 227 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 57%

Win Rate 107 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 55%

Win Rate 275 Games

Exhaust Flash

Third Best

Cassiopeia's 3rd Best Summoner Spells 55%

Win Rate 60 Games

Cleanse Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 45%

Win Rate 20 Games

  • 1
  • 2
  • 3
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Trinket

Cassiopeia's Best Trinket 55%

Win Rate 478 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 51%

Win Rate 564 Games

Stealth Ward

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 98 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 50%

Win Rate 2 Games

  • 1
  • 2
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Cassiopeia Counters

Learn 's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Cassiopeia Mid in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Cassiopeia Skins

Cassiopeia's Abilities

Questions About Cassiopeia

Ask

Latest Questions

Feeling difficult to deal damage to mages who build RoA, what should I do?

Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...

View (4) Answers

Which way is Katarina facing when she ults?

If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?

View (2) Answers

Question on Cassiopeia

I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...

View (2) Answers

Who should i choose?

???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]

View (3) Answers

Who is the most OP champion in the game?

I am wondering who is the most OP champion to play. I wanna see how well I can do.

View (23) Answers

What are some fun or brainless champions?

I have no idea who I should buy; any suggestions?

View (8) Answers

Was Cassiopeia recently buffed?

Title.

View (1) Answers

cassiopeia at bot lane

has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...

View (4) Answers

Timing of a DoTs first "tick"

So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....

View (0) Answers

Lich bane Cass

So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options

View (2) Answers

Next AP Mid to learn and why?

Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...

View (4) Answers

League of Legends Champions:

Teamfight Tactics Guide