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Cassiopeia Build Guides, Runes and Items

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends S13 Patch 13.11. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S13 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!

Season 13 Guides // Patch 13.11 & Patch 13.10
9.5
461
Votes
25
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[ NEW SEASON 13 - 13.11 UPDATED!! ] CASSIOPEIA - The POISON Queen of Midlane ☠ 💀

Guide by RezoneVerified updated June 1, 2023
  • In-depth
8.3
67
Votes
11
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Raen's Cassiopeia (°,,°) Tips & Build

Guide by Raen updated May 27, 2023
New Guide
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

S13 - Challenger Cassiopeia Guide

Guide by Yurox updated May 31, 2023
  • In-depth
Season 13 Guides // Other Patches
8.7
24
Votes
4
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[12.21] Zethal's Grandmaster Cassiopeia Guide - 64% WR IN GM

Guide by Zethal_Na updated December 4, 2022
  • In-depth
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Masters Cassiopeia Guide to Playing Snek!

Guide by Zeusman00 updated May 16, 2023
  • In-depth
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[13.9] Master Cassiopeia battlemage queen. Tanky approach to cass

Guide by zuboun159 updated May 8, 2023
Season 13 Builds // Patch 13.11 & Patch 13.10
New Guide
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Queen Cobra Cass (Bot Lane CARRY)

Build by Faxual updated May 31, 2023
Season 13 Builds // Other Patches
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Snake build 🐍

Build by Budgizee updated February 2, 2023
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

S13 Cassiopeia

Build by hughjanis99 updated January 13, 2023
Season 12 Guides
10
1200
Votes
50
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Yeager's Master Cassiopeia Guide

Guide by Yeager updated April 20, 2022
  • In-depth
9.8
50
Votes
4
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[S12] Ultimate MASTERS+ Cassiopeia || Build Exodia and 1v9

Guide by xLessThanThree updated November 30, 2021
  • In-depth
9.5
282
Votes
16
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Hyrav's Challenger Rank 1 Cassiopeia Guide

Guide by Hyrav updated August 2, 2022
  • In-depth
9.1
22
Votes
2
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

yer's Recommended botlane [preseason 12 update]

Guide by yers updated November 22, 2021
  • In-depth
8.5
8
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Huntervault's Gargoyle Cassiopeia Guide

Guide by Huntervault updated January 24, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia Build Guide Season 12 (low ELO)

Guide by Mvrshy updated August 13, 2022
  • In-depth
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Anithero Cassiopeia Guide

Guide by Flipps updated April 9, 2022
  • Off-Meta
5.6
2
Votes
10
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Casseiessippi

Guide by BowlOfSoup updated January 20, 2022
  • Off-Meta
Season 12 Builds
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassio

Build by Kyster Draven updated February 10, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia mid-late powerspike

Build by Guest updated January 26, 2022
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia

Build by Guest updated October 7, 2022
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Cassiopeia Build & Runes

If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 13.11. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!

Patch 13.11: 899696 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 52%

Win Rate 9556 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Second Best

Cassiopeia's 2nd Best Runes 53%

Win Rate 2684 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Third Best

Cassiopeia's 3rd Best Runes 54%

Win Rate 1953 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 52%

Win Rate 16983 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 53%

Win Rate 2779 Games

Flash Ghost

Third Best

Cassiopeia's 3rd Best Summoner Spells 52%

Win Rate 2382 Games

Flash Ignite

Cassiopeia's Starters

Cassiopeia's Best Starter Items 52%

Win Rate 57534 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 48%

Win Rate 12358 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 55%

Win Rate 8119 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 56%

Win Rate 5139 Games

Oracle Lens
Don’t forget
to Buy Wards
Patch 13.11: 899651 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 53%

Win Rate 1983 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Second Best

Cassiopeia's 2nd Best Runes 61%

Win Rate 240 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 764 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 54%

Win Rate 5035 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 54%

Win Rate 305 Games

Exhaust Flash

Third Best

Cassiopeia's 3rd Best Summoner Spells 52%

Win Rate 251 Games

Flash Ignite

Cassiopeia's Starters

Cassiopeia's Best Starter Items 53%

Win Rate 12731 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 50%

Win Rate 3145 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 58%

Win Rate 1720 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 56%

Win Rate 1224 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia Counters

Learn Cassiopeia's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Cassiopeia Mid in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Cassiopeia Skins

Cassiopeia's Abilities

Questions About Cassiopeia

Ask

Latest Questions

Feeling difficult to deal damage to mages who build RoA, what should I do?

Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...

View (4) Answers

Which way is Katarina facing when she ults?

If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?

View (2) Answers

Question on Cassiopeia

I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...

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Who should i choose?

???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]

View (3) Answers

Who is the most OP champion in the game?

I am wondering who is the most OP champion to play. I wanna see how well I can do.

View (23) Answers

What are some fun or brainless champions?

I have no idea who I should buy; any suggestions?

View (8) Answers

Was Cassiopeia recently buffed?

Title.

View (1) Answers

cassiopeia at bot lane

has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...

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Timing of a DoTs first "tick"

So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....

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Lich bane Cass

So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options

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Next AP Mid to learn and why?

Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...

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