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Cassiopeia Build Guides, Runes and Items

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends S13 Patch 12.22. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S13 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!

Season 10 Guides
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Begginner guide/ All matchups

Guide by Guest updated October 9, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Forkos's Cassiopeia Guide

Guide by Guest updated May 22, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia in detail

Guide by Guest updated March 16, 2020
Season 10 Builds
7.9
15
Votes
4
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Aniki's Conqueror Cassiopeia Guide

Build by AnikiTaka updated December 9, 2019
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

RRRRRANK 1 CASSIOPIA(Pun1sher)

Build by Guest updated August 15, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

The tankiopea

Build by SwrdMaster updated August 9, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Season 10 Cassiopeia Runes and Build

Build by SawyerNelson updated December 10, 2019
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

The Fat Snake - Cassiopeia Mid

Build by Guest updated April 29, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

D3jvy ' s Cassiopeia Guide :D

Build by D3jvy updated January 29, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

The only Cassiopeia Guide you'll ever need!

Build by riveru shen updated January 28, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Mid Lane Guide

Build by Faithyatta updated November 5, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cass yo pya [10.17]

Build by nusc updated August 27, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Mid (Conq)

Build by SaimonsJuniorLP updated July 14, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[ 10.10 ] [ mid ] Cassiopeia

Build by Im uta updated May 15, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Totally a legit cassiopeia guide

Build by Craken18 updated May 4, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Mid Lane Cassiopeia Guide

Build by LightningDeceptigon updated February 23, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Ultimate Cassiopeia Mid's Guide

Build by Shyokapik updated December 7, 2019
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia

Build by XD Crabby updated December 6, 2019
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cass supp

Build by Guest updated March 30, 2020
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopiea jungle

Build by Guest updated July 27, 2020
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Cassiopeia Build & Runes

If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 12.22. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!

Patch 12.22: 423252 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 50%

Win Rate 2733 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Second Best

Cassiopeia's 2nd Best Runes 66%

Win Rate 65 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Treasure Hunter
Treasure Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 66%

Win Rate 65 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Unflinching
Unflinching
LoL Rune: Bone Plating
Bone Plating

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 4873 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 51%

Win Rate 4011 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 53%

Win Rate 1922 Games

Flash Ghost

Cassiopeia's Starters

Cassiopeia's Best Starter Items 51%

Win Rate 9738 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 7755 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 53%

Win Rate 4261 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 1431 Games

Oracle Lens
Don’t forget
to Buy Wards
Patch 12.22: 423256 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 57%

Win Rate 83 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Second Best

Cassiopeia's 2nd Best Runes 55%

Win Rate 177 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Third Best

Cassiopeia's 3rd Best Runes 53%

Win Rate 94 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 62%

Win Rate 103 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 57%

Win Rate 338 Games

Flash Ghost

Third Best

Cassiopeia's 3rd Best Summoner Spells 50%

Win Rate 832 Games

Flash Teleport

Cassiopeia's Starters

Cassiopeia's Best Starter Items 52%

Win Rate 1509 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 1119 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 53%

Win Rate 593 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 56%

Win Rate 283 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 63%

Win Rate 83 Games

  • 1
  • 2
Patch 12.22: 171634 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 47%

Win Rate 109 Games

  • 1
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Second Best

Cassiopeia's 2nd Best Runes 0%

Win Rate Games

LoL Path:

LoL Path:

Third Best

Cassiopeia's 3rd Best Runes 0%

Win Rate Games

LoL Path:

LoL Path:

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 59%

Win Rate 123 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 53%

Win Rate 81 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 53%

Win Rate 62 Games

Flash Ignite

Cassiopeia's Starters

Cassiopeia's Best Starter Items 0%

Win Rate Games

! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Trinket

Cassiopeia's Best Trinket 60%

Win Rate 227 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 52%

Win Rate 67 Games

Oracle Lens

Third Best

Cassiopeia's 3rd Best Trinket 47%

Win Rate 315 Games

Stealth Ward
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 0%

Win Rate Games

  • 1
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Cassiopeia Counters

Learn Cassiopeia's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Cassiopeia Mid in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Cassiopeia Skins

Cassiopeia's Abilities

Questions About Cassiopeia

Ask

Latest Questions

Feeling difficult to deal damage to mages who build RoA, what should I do?

Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...

View (4) Answers

Which way is Katarina facing when she ults?

If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?

View (2) Answers

Question on Cassiopeia

I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...

View (2) Answers

Who should i choose?

???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]

View (3) Answers

Who is the most OP champion in the game?

I am wondering who is the most OP champion to play. I wanna see how well I can do.

View (23) Answers

What are some fun or brainless champions?

I have no idea who I should buy; any suggestions?

View (8) Answers

Was Cassiopeia recently buffed?

Title.

View (1) Answers

cassiopeia at bot lane

has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...

View (4) Answers

Timing of a DoTs first "tick"

So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....

View (0) Answers

Lich bane Cass

So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options

View (2) Answers

Next AP Mid to learn and why?

Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...

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