Vayne Build Guides, Runes and Items

If you're looking for the best rune build for Vayne we've got you covered. Below you can find the best items and runes to build for Vayne, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Vayne this is a great resource to quickly get a good rune selection for Patch 13.1. However, if you are a new Vayne player we highly recommend reading through some of the guides above to learn why this build is strong on Vayne!

Learn Vayne's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Vayne guides to see how to build and play against other champions you may find yourself up against!

This counter data is for Vayne ADC in Plat+ games. The percent shown is the enemy champion's counter rating against Vayne. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.