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LoL Champion Build Guides: Karthus

Karthus RP Cost 790 Karthus BE Cost3150
Pick 78%
Win 51%
Pick 12%
Win 54%
Pick 8%
Win 51%
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Karthus The Deathsinger

Find the best Karthus build guides for League of Legends Patch 10.21. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Karthus build for the S10 meta. Learn more about Karthus' abilities, skins, or even ask your own questions to the community!


Season 10 Guides
LoL Champion Karthus Build Guide

10.21 Karthus ADC guide

Guide by ELOSANTA updated October 24, 2020
  • 10.21
Votes: 42
Views: 107,924
LoL Champion Karthus Build Guide

2.2 Million Mastery - New Items - Lane Karthus Guide - Patc

Guide by Hullos updated October 17, 2020
  • 10.21
  • In-depth
Votes: 16
Views: 29,862
LoL Champion Karthus Build Guide

BEST JUNGLER IN THE META Challenger karthus jgl guide

Guide by KamiKZ updated October 23, 2020
  • 10.21
Votes: 17
Views: 53,630
LoL Champion Karthus Build Guide

Diamond Tank Karthus - Swift Death

Guide by Aqua Dragon updated October 15, 2020
  • 10.21
  • In-depth
Votes: 95
Views: 1,227,848
LoL Champion Karthus Build Guide

Karthus - Ghost Wind Demon

Guide by Shrewdo updated October 22, 2020
  • 10.21
  • In-depth
Votes: 9
Views: 37,574
LoL Champion Karthus Build Guide

Embody death itself! (1k AP) (Mid and Top)

Guide by CaptianMike updated October 1, 2020
  • 10.20
Votes: 575
Views: 1,912,944
LoL Champion Karthus Build Guide

[10.21] Karthus Jungle Guide | Not just an R Machine

Guide by nZk01 updated October 14, 2020
  • 10.21
Votes: 139
Views: 432,570
LoL Champion Karthus Build Guide

[S10] TwistedDemon's Karthus Guide

Guide by TwistedDemon updated September 25, 2020
  • 10.19
Votes: 10
Views: 2,126
LoL Champion Karthus Build Guide

Suicide Karthus (ARAM)

Guide by cirque_du_loleil updated September 15, 2020
  • 10.18
Rating Pending
Views: 1,193
LoL Champion Karthus Build Guide

[70% Winrate] Rank #84 Karthus In The World Guide (MID)

Guide by DingDongGaming updated August 23, 2020
  • 10.17
Votes: 291
Views: 1,189,825
LoL Champion Karthus Build Guide

DO FEAR THE REAPER! - KARTHUS SUPPORT

Guide by snukumz updated July 26, 2020
  • 10.15
  • In-depth
Votes: 56
Views: 136,761
LoL Champion Karthus Build Guide

The Karthus Community Guide

Guide by The PaIe King updated July 26, 2020
  • 10.15
  • In-depth
Votes: 141
Views: 364,703
LoL Champion Karthus Build Guide

[10.15] Quick Challenger Karthus Guide

Guide by Kasugunai updated July 27, 2020
  • 10.15
Rating Pending
Views: 3,783
LoL Champion Karthus Build Guide

NEW [10.15] Karthus JG Complete Guide - KingStix - Challenge

Guide by KingStix updated July 21, 2020
  • 10.14
Votes: 20
Views: 18,554
Season 10 Builds
LoL Champion Karthus Build Guide

The Grim Reaper (Jungle)

Build by ObserverOfTime updated October 4, 2020
  • 10.20
Rating Pending
Views: 678
LoL Champion Karthus Build Guide

Karthus Jesuscirraptor TOP Tank

Build by Jesuscirraptor updated September 28, 2020
  • 10.19
Rating Pending
Views: 2,836
LoL Champion Karthus Build Guide

Karthus: the deathsinger

Build by AkimboTs updated September 28, 2020
  • 10.19
Rating Pending
Views: 332
LoL Champion Karthus Build Guide

Karthus Jesuscirraptor MID Mana Glass Cannon

Build by Jesuscirraptor updated September 28, 2020
  • 10.19
Rating Pending
Views: 1,271
LoL Champion Karthus Build Guide

Karthus "Deathsinger" Guide

Build by TheMoshi updated September 22, 2020
  • 10.19
Rating Pending
Views: 543
LoL Champion Karthus Build Guide

Karthus the Kill Thief

Build by Guest updated September 18, 2020
  • 10.19
Rating Pending
Views: 194
1 2 3 4 5 6 7 8 28 48

Karthus Build Stats

Patch 10.21: 585736 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 51%

Win Rate 9837 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Second Best

Karthus's 2nd Best Runes 55%

Win Rate 2024 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 55%

Win Rate 812 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Karthus's Summoner Spells

Karthus's Best Summoner Spells 50%

Win Rate 23249 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 55%

Win Rate 588 Games

Exhaust Smite

Third Best

Karthus's 3rd Best Summoner Spells 56%

Win Rate 72 Games

Smite Ignite

Karthus's Starters

Karthus's Best Starter Items 50%

Win Rate 23569 Games

  • 1
  • 2

Trinket

Karthus's Best Trinket 51%

Win Rate 15981 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 46%

Win Rate 6574 Games

Warding Totem

Third Best

Karthus's 3rd Best Trinket 49%

Win Rate 1402 Games

Farsight Alteration
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 67%

Win Rate 3705 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Ability Order 66%

Win Rate 1267 Games

Third Best

Karthus's 3rd Best Ability Order 61%

Win Rate 98 Games

Patch 10.21: 585737 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 56%

Win Rate 1381 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Second Best

Karthus's 2nd Best Runes 63%

Win Rate 76 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 55%

Win Rate 495 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Karthus's Summoner Spells

Karthus's Best Summoner Spells 56%

Win Rate 2265 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 54%

Win Rate 498 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 50%

Win Rate 284 Games

Flash Heal

Karthus's Starters

Karthus's Best Starter Items 55%

Win Rate 3300 Games

  • 1

Trinket

Karthus's Best Trinket 57%

Win Rate 1586 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 52%

Win Rate 1449 Games

Warding Totem

Third Best

Karthus's 3rd Best Trinket 54%

Win Rate 152 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 69%

Win Rate 129 Games

  • 1
  • 2
Patch 10.21: 585739 matches scanned * Each section of the build is rated independently of the others

Karthus's Runes

Karthus's Best Runes 63%

Win Rate 147 Games

  • 1
  • 2
  • 3
Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Cheap Shot
Cheap Shot
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Second Best

Karthus's 2nd Best Runes 60%

Win Rate 139 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ravenous Hunter
Ravenous Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Last Stand
Last Stand

Third Best

Karthus's 3rd Best Runes 59%

Win Rate 83 Games

Domination
LoL Path: Domination
LoL Rune: Dark Harvest
Dark Harvest
LoL Rune: Taste of Blood
Taste of Blood
LoL Rune: Eyeball Collection
Eyeball Collection
LoL Rune: Ultimate Hunter
Ultimate Hunter

Precision
LoL Path: Precision
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Coup de Grace
Coup de Grace

Karthus's Summoner Spells

Karthus's Best Summoner Spells 54%

Win Rate 1379 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Summoner Spells 50%

Win Rate 1087 Games

Flash Teleport

Third Best

Karthus's 3rd Best Summoner Spells 56%

Win Rate 353 Games

Flash Ignite

Karthus's Starters

Karthus's Best Starter Items 52%

Win Rate 3812 Games

  • 1
  • 2

Trinket

Karthus's Best Trinket 50%

Win Rate 2002 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Trinket 57%

Win Rate 965 Games

Farsight Alteration

Third Best

Karthus's 3rd Best Trinket 55%

Win Rate 198 Games

Oracle Lens
Don’t forget
to Buy Wards

Karthus's Ability Order

Karthus's Best Ability Order 70%

Win Rate 289 Games

  • 1
  • 2
  • 3

Second Best

Karthus's 2nd Best Ability Order 67%

Win Rate 287 Games

Third Best

Karthus's 3rd Best Ability Order 58%

Win Rate 52 Games

Karthus Skins

Karthus' Abilities

Ability Range Cost Cooldown
Karthus's Death Defied
Death Defied Karthus's Passive Karthus's Passive
Self
Karthus's Passive
Karthus's Passive
Upon dying, Karthus enters a spirit form allowing him to continue casting spells for 7 seconds. During this time his abilities cost no mana.
Q
Karthus's Lay Waste
Lay Waste Karthus's Q Ability
875
20 / 26 / 32 / 38 / 44
1
Karthus briefly reveals the target area which he detonates after a 0.5-second delay, dealing 50 / 70 / 90 / 110 / 130 (+30% of ability power) magic damage to all enemies within, doubled when hitting only one target.

Lay Waste's damage is reduced by 15% against monsters.

During Death Defied, Lay Waste will cast at maximum range if cast beyond that.
W
Karthus's Wall of Pain
Wall of Pain Karthus's W Ability
1000
70
15
Karthus creates a 800 / 900 / 1000 / 1100 / 1200 distance wide wall at the target location for 5 seconds. The wall reduces the magic resistance of enemies who pass through it by 15% for 5 seconds and applies a 40 / 50 / 60 / 70 / 80% slow which drops to half effectiveness after 1 second and then decays over the remaining debuff duration.
E
Karthus's Defile
Defile Karthus's E Ability
425
30 / 42 / 54 / 66 / 78
0.5
Passive: Karthus restores 20 / 27 / 34 / 41 / 48 mana whenever he kills an enemy.

Toggle: Drains 30 / 42 / 54 / 66 / 78 Mana every second. Deals 7.5 / 12.5 / 17.5 / 22.5 / 27.5 (+5% of ability power) magic damage every 0.25 seconds to all nearby enemies. Deactivating Defile deals 1 tick's worth of damage.

Defile cannot be toggled off during Death Defied, but it can be while channeling Requiem.
R
Karthus's Requiem
Requiem Karthus's Ultimate (R) Ability
Self
100
200 / 180 / 160 / 160 / 160
After channeling for 3 seconds, Karthus deals 200 / 350 / 500 (+75% of ability power) magic damage to all enemy champions (regardless of distance).

Questions About Karthus

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