Cassiopeia Build Guides, Runes and Items
Cassiopeia The Serpent's Embrace
Find the best Cassiopeia build guides for League of Legends S13 Patch 13.23. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S13 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!
Season 8 Cassawin
![]()
% 100 w rate Twisted Treeline Cass
% 100 w rate Twisted Treeline Cass
Snakerunes, Cassio after the Runes rework.
![]()
Took me to Master with Cassiopeia in S6, OTP Guide
![]()
A complete and detailed guide to master the Snake (**WIP**)
![]()
Cassiopeia, The Sneaky Snakey SoloQ Monster
Throwing A Mid Lane Hissy Fit
![]()
AP Carry Cassiopeia
![]()
[7.17]"There is No Antidote for Me"
![]()
This is a stupid idea
Cassiopeia Mid [S7]
CASSIOPEIA DEADLY BUILD
CASSIOPEIA TOP
Cassiopeia Build
![]()
Cassiopeia
S7 New build CASSIOPEIA
The snake without an antidote
![]()
CASSIOPEIA HEALING GUIDE
![]()
Cassiopeia 1v9
![]()
main cassiopeia guide
Cassiopeia Build & Runes
If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 13.23. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!
* Each section of the build is rated independently of the others
Cassiopeia's Runes
51%
Win Rate 64% Pickrate
- 1
- 2
- 3
Second Best
51%
Win Rate 16% Pickrate
Third Best
49%
Win Rate 14% Pickrate
Cassiopeia's Summoner Spells
51%
Win Rate 75% Pickrate
- 1
- 2
- 3
Cassiopeia's Starters
51%
Win Rate 80% Pickrate
- 1
- 2
- 3
Cassiopeia's Core Items
57%
Win Rate 17% Pickrate
- 1
- 2
- 3
Cassiopeia's Luxury Items
Cassiopeia's Ability Order
50%
Win Rate 60% Pickrate
- 1
- 2
- 3
Serpentine Grace (PASSIVE)
Passive Ability
Second Best
54%
Win Rate 18% Pickrate
Serpentine Grace (PASSIVE)
Passive Ability
Third Best
49%
Win Rate 4% Pickrate
Serpentine Grace (PASSIVE)
Passive Ability
* Each section of the build is rated independently of the others
Cassiopeia's Runes
52%
Win Rate 65% Pickrate
- 1
- 2
- 3
Second Best
51%
Win Rate 15% Pickrate
Third Best
49%
Win Rate 13% Pickrate
Cassiopeia's Summoner Spells
52%
Win Rate 84% Pickrate
- 1
- 2
- 3
Cassiopeia's Starters
52%
Win Rate 79% Pickrate
- 1
- 2
- 3
Cassiopeia's Core Items
53%
Win Rate 12% Pickrate
- 1
- 2
- 3
Cassiopeia's Luxury Items
Cassiopeia's Ability Order
51%
Win Rate 48% Pickrate
- 1
- 2
- 3
Serpentine Grace (PASSIVE)
Passive Ability
Second Best
54%
Win Rate 29% Pickrate
Serpentine Grace (PASSIVE)
Passive Ability
Third Best
51%
Win Rate 5% Pickrate
Serpentine Grace (PASSIVE)
Passive Ability
* Each section of the build is rated independently of the others
Cassiopeia's Runes
54%
Win Rate 69% Pickrate
- 1
- 2
- 3
Second Best
49%
Win Rate 12% Pickrate
Third Best
53%
Win Rate 9% Pickrate
Cassiopeia's Summoner Spells
53%
Win Rate 43% Pickrate
- 1
- 2
- 3
Cassiopeia's Starters
57%
Win Rate 76% Pickrate
- 1
- 2
- 3
Cassiopeia's Core Items
49%
Win Rate 15% Pickrate
- 1
- 2
- 3
Cassiopeia's Luxury Items
Cassiopeia's Ability Order
53%
Win Rate 62% Pickrate
- 1
- 2
- 3
Serpentine Grace (PASSIVE)
Passive Ability
Second Best
59%
Win Rate 18% Pickrate
Serpentine Grace (PASSIVE)
Passive Ability
Third Best
51%
Win Rate 3% Pickrate
Serpentine Grace (PASSIVE)
Passive Ability
Cassiopeia Counters
Learn Cassiopeia's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!
This counter data is for Cassiopeia MIDDLE in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.
Best Against Cassiopeia
Worst Against Cassiopeia
Cassiopeia Skins
Find Cassiopeia's skins and when they were last on sale. Never miss a sale for your favorite skin by using our Wish List feature! You can also find all Cassiopeia skins and chromas on Cassiopeia's skins page.
Wishlist
Our Wish List feature will send you notifications when your skins are on sale!Cassiopeia's Abilities
If this kills the target, this ability's cooldown is refunded.
Questions About Cassiopeia
Latest Questions
Feeling difficult to deal damage to mages who build RoA, what should I do?
Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...
Which way is Katarina facing when she ults?
If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?
Question on Cassiopeia
I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...
Who should i choose?
???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]
Who is the most OP champion in the game?
I am wondering who is the most OP champion to play. I wanna see how well I can do.
What are some fun or brainless champions?
I have no idea who I should buy; any suggestions?
Was Cassiopeia recently buffed?
Title.
cassiopeia at bot lane
has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...
Timing of a DoTs first "tick"
So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....
Lich bane Cass
So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options
Next AP Mid to learn and why?
Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...
