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Cassiopeia Build Guides, Runes and Items

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends S12 Patch 12.19. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S12 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!

Season 5 Builds
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Quick Cassiopeia Build [Mid]

Build by Hi_Im_Lunar updated April 15, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassi mid penetration

Build by Guest updated March 19, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Team ONS Cassiopeia Midlane

Build by ONS Pr0Archer updated March 19, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassio Top Lane

Build by Yunoik updated March 2, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia, the Kite/Chase Master

Build by TheFonz07 updated February 24, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Sneaky Snake

Build by Guest updated February 7, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

New Cassiopeia S5 Jungle

Build by Solunatico updated January 31, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia ARAM

Build by laggef updated January 27, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia - Arbok uses Toxic

Build by yimyo2020 updated January 23, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia, The Serpent's Embrace

Build by N1ghtly updated January 16, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Off Tank Guide Top, Mid

Build by EgoluCassiopeia updated January 9, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

《역삼건마〉bamwar4+밤전〈인천오피》

Build by sentajoelle9 updated January 1, 2015
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

[AP] Unstopuble Mid

Build by MyLips updated December 24, 2014
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

DPS/TANK (the ancient anaconda)

Build by Guest updated December 6, 2014
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

aka MonkeyFace

Build by Torred updated November 21, 2014
Season 4 Guides
9.5
53
Votes
2
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia - The Venomous Monarch

Guide by BlackIceT updated January 1, 2014
  • In-depth
8.8
10
Votes
0
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Ecco's Cassiopeia Guide

Guide by MRN.ecco updated January 6, 2014
  • In-depth
7.7
170
Votes
26
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia: The Serpent's Embrace (In-Depth)

Guide by Commercialized updated December 1, 2013
  • In-depth
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Jungle Snakes rule! How does that even work?

Guide by Irtehstuff updated April 13, 2014
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

CassiOPeia, The Serpents Embrace

Guide by thekatalist updated December 17, 2013
  • In-depth
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Cassiopeia Build & Runes

If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 12.19. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!

Patch 12.16: 469470 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 52%

Win Rate 2856 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Second Best

Cassiopeia's 2nd Best Runes 63%

Win Rate 83 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Resolve
LoL Path: Resolve
LoL Rune: Unflinching
Unflinching
LoL Rune: Bone Plating
Bone Plating

Third Best

Cassiopeia's 3rd Best Runes 61%

Win Rate 190 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 5885 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 51%

Win Rate 4116 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 52%

Win Rate 1797 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 52%

Win Rate 11181 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 50%

Win Rate 8659 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 54%

Win Rate 5136 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 1722 Games

Oracle Lens
Don’t forget
to Buy Wards
Patch 12.16: 469470 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 55%

Win Rate 209 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Second Best

Cassiopeia's 2nd Best Runes 55%

Win Rate 157 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Sorcery
LoL Path: Sorcery
LoL Rune: Transcendence
Transcendence
LoL Rune: Manaflow Band
Manaflow Band

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 229 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Resolve
LoL Path: Resolve
LoL Rune: Conditioning
Conditioning
LoL Rune: Overgrowth
Overgrowth

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 1092 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 52%

Win Rate 711 Games

Flash Ignite

Third Best

Cassiopeia's 3rd Best Summoner Spells 55%

Win Rate 220 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 51%

Win Rate 1858 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 51%

Win Rate 1390 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 52%

Win Rate 805 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 56%

Win Rate 328 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 72%

Win Rate 127 Games

  • 1
  • 2
Patch 11.20: 494917 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 62%

Win Rate 55 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 53%

Win Rate 169 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 227 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 57%

Win Rate 107 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 55%

Win Rate 275 Games

Exhaust Flash

Third Best

Cassiopeia's 3rd Best Summoner Spells 55%

Win Rate 60 Games

Cleanse Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 45%

Win Rate 20 Games

  • 1
  • 2
  • 3
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Trinket

Cassiopeia's Best Trinket 55%

Win Rate 478 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 51%

Win Rate 564 Games

Stealth Ward

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 98 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 50%

Win Rate 2 Games

  • 1
  • 2
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Cassiopeia Counters

Learn 's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Cassiopeia Mid in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Cassiopeia Skins

Cassiopeia's Abilities

Questions About Cassiopeia

Ask

Latest Questions

Feeling difficult to deal damage to mages who build RoA, what should I do?

Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...

View (4) Answers

Which way is Katarina facing when she ults?

If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?

View (2) Answers

Question on Cassiopeia

I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...

View (2) Answers

Who should i choose?

???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]

View (3) Answers

Who is the most OP champion in the game?

I am wondering who is the most OP champion to play. I wanna see how well I can do.

View (23) Answers

What are some fun or brainless champions?

I have no idea who I should buy; any suggestions?

View (8) Answers

Was Cassiopeia recently buffed?

Title.

View (1) Answers

cassiopeia at bot lane

has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...

View (4) Answers

Timing of a DoTs first "tick"

So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....

View (0) Answers

Lich bane Cass

So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options

View (2) Answers

Next AP Mid to learn and why?

Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...

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