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LoL Champion Build Guides: Cassiopeia

Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends S12 Patch 12.1. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S12 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!

Season 1 Guides
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Belladonna

Guide by Misentro updated June 29, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

A Tanking Snake

Guide by Xofrevihs updated September 27, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

In Action: Cassiopeia

Guide by Skittlz29 updated June 20, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

The devistating Cassiopia

Guide by nikolac234 updated June 30, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia, The Snake of the West

Guide by El Sousu Que updated October 16, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Serpentine Pattern! Serpentine Pattern!

Guide by cheste updated September 30, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Beginner's Cass

Guide by Draaen updated September 3, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

What the?

Guide by wacky13 updated June 15, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Noxious blast destruction

Guide by Victra updated June 15, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cass Two Shooter

Guide by TopStoner1 updated June 15, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

a noob guide cassio :D

Guide by JLAS01 updated July 7, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia-Poison eve,is the least of your worries

Guide by jasonosaj updated July 27, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Survival Cassie

Guide by Astricon updated July 14, 2011
Season 1 Builds
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia- Surrender to her !

Build by bLaxnow updated August 30, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Dominion Harass Casseiopeia

Build by Guest updated November 8, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia - Quickie Guide

Build by Holom updated September 18, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cass ap and heal

Build by jerry41 updated August 16, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia Mana/AP

Build by th3le0 updated August 13, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

Cassiopeia - Toxic Fangs

Build by Whidez updated August 4, 2011
Rating Pending
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

cassiopeia: the most OP caster in the game

Build by markuswurtz updated September 12, 2011
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Cassiopeia Build & Runes

If you're looking for the best rune build for Cassiopeia we've got you covered. Below you can find the best items and runes to build for Cassiopeia, as determined by LeagueSpy's calculations of thousands of Plat+ League of Legends games. If you are already familiar with how to play Cassiopeia this is a great resource to quickly get a good rune selection for Patch 12.1. However, if you are a new Cassiopeia player we highly recommend reading through some of the guides above to learn why this build is strong on Cassiopeia!

Patch 12.1: 393585 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Top Items

Cassiopeia's Runes

Cassiopeia's Best Runes 51%

Win Rate 4134 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 49%

Win Rate 2764 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 1998 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood
More Cassiopeia Runes

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 51%

Win Rate 10801 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 50%

Win Rate 8463 Games

Flash Ignite

Third Best

Cassiopeia's 3rd Best Summoner Spells 51%

Win Rate 3461 Games

Flash Barrier

Cassiopeia's Starters

Cassiopeia's Best Starter Items 51%

Win Rate 19943 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 15582 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 54%

Win Rate 7727 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 51%

Win Rate 3789 Games

Oracle Lens
Don’t forget
to Buy Wards

Top Cassiopeia Players

Get match statisctics & builds Top Cassiopeia Players are using on LeagueSpy!

Patch 12.1: 393589 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Top Items

Cassiopeia's Runes

Cassiopeia's Best Runes 52%

Win Rate 758 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 54%

Win Rate 520 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 58%

Win Rate 71 Games

Sorcery
LoL Path: Sorcery
LoL Rune: Phase Rush
Phase Rush
LoL Rune: Manaflow Band
Manaflow Band
LoL Rune: Transcendence
Transcendence
LoL Rune: Gathering Storm
Gathering Storm

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood
More Cassiopeia Runes

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 50%

Win Rate 3687 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 51%

Win Rate 1044 Games

Flash Ignite

Third Best

Cassiopeia's 3rd Best Summoner Spells 53%

Win Rate 341 Games

Flash Barrier

Cassiopeia's Starters

Cassiopeia's Best Starter Items 50%

Win Rate 4326 Games

  • 1
  • 2

Trinket

Cassiopeia's Best Trinket 49%

Win Rate 3238 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 53%

Win Rate 1568 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 51%

Win Rate 869 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 64%

Win Rate 650 Games

  • 1
  • 2

Top Cassiopeia Players

Get match statisctics & builds Top Cassiopeia Players are using on LeagueSpy!

Patch 11.20: 494917 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Top Items

Cassiopeia's Runes

Cassiopeia's Best Runes 62%

Win Rate 55 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 53%

Win Rate 169 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 227 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood
More Cassiopeia Runes

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 57%

Win Rate 107 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 55%

Win Rate 275 Games

Exhaust Flash

Third Best

Cassiopeia's 3rd Best Summoner Spells 55%

Win Rate 60 Games

Cleanse Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 45%

Win Rate 20 Games

  • 1
  • 2
  • 3
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Trinket

Cassiopeia's Best Trinket 55%

Win Rate 478 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 51%

Win Rate 564 Games

Stealth Ward

Third Best

Cassiopeia's 3rd Best Trinket 54%

Win Rate 98 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 50%

Win Rate 2 Games

  • 1
  • 2
! Small Sample Size Warning * There is either not a lot of games played on this champion or the builds vary greatly, we have provided the top build but it does not have a high confidence rating so use your own discretion.

Top Cassiopeia Players

Get match statisctics & builds Top Cassiopeia Players are using on LeagueSpy!

Cassiopeia Counters

Learn 's counters and discover matchups where they have an advantage! When you're starting a game of League of Legends you should always keep in mind if you'll be at an advantage or disadvantage against your opponent, so you can know whether to bully them or play safe. You can find detailed breakdowns of each matchup on CounterStats, and you can also check out some Cassiopeia guides to see how to build and play against other champions you may find yourself up against!


This counter data is for Cassiopeia Mid in Plat+ games. The percent shown is the enemy champion's counter rating against Cassiopeia. Counter rating is our own statistic that factors in counter kills, overall kills, early lead ratio, comeback ratio, and win percent to give the whole picture of that champion's effectiveness as a counter pick.

Cassiopeia Skins

Cassiopeia's Abilities

Cassiopeia's Serpentine Grace
Serpentine Grace Cassiopeia's Passive Cassiopeia's Passive
Self
Cassiopeia's Passive
Cassiopeia's Passive
Cassiopeia gains 4 Movement Speed per level. Cassiopeia cannot purchase Boots items.
Q
Cassiopeia's Noxious Blast
Noxious Blast Cassiopeia's Q Ability
850
50 / 60 / 70 / 80 / 90
3.5
Cassiopeia blasts an area with a delayed high damaging poison, dealing 75 / 110 / 145 / 180 / 215 (+90% of ability power) magic damage over 3 seconds and granting her 30 / 35 / 40 / 45 / 50% movement speed which decays over 3 seconds if she hits a champion.
W
Cassiopeia's Miasma
Miasma Cassiopeia's W Ability
700
70 / 80 / 90 / 100 / 110
24 / 22 / 20 / 18 / 16
Cassiopeia spews venom in an arc in front of her, leaving toxic clouds for 5 seconds. Enemies in the cloud take 20 / 25 / 30 / 35 / 40 (+15% of ability power) magic damage per second, are slowed by 40 / 50 / 60 / 70 / 80% (decays over the duration) and are grounded, prohibiting the use of movement abilities.
E
Cassiopeia's Twin Fang
Twin Fang Cassiopeia's E Ability
700
50 / 48 / 46 / 44 / 42
0.75
Cassiopeia deals 48 (+4x champion level) (+10% of ability power) magic damage to her target.

If the target is poisoned, Twin Fang deals 20 / 40 / 60 / 80 / 100 (+60% of ability power) bonus magic damage and restores 12 / 14 / 16 / 18 / 20% of Cassiopeia's ability power to her as health. This heal is 75% less effective against minions and small monsters.

If Twin Fang kills a unit, its mana cost is refunded.
R
Cassiopeia's Petrifying Gaze
Petrifying Gaze Cassiopeia's Ultimate (R) Ability
825
100
120 / 100 / 80 / 80 / 80
Cassiopeia releases a swirl of magical energy from her eyes, dealing 150 / 250 / 350 (+50% of ability power) magic damage to all enemies in front of her. Enemies facing her are stunned for 2 seconds, while enemies facing away are slowed by 40% for the same duration.

Questions About Cassiopeia

Ask

Latest Questions

Feeling difficult to deal damage to mages who build RoA, what should I do?

Situation: In the early-mid game, I built Morellonomicon, opponent built RoA. Problem: Feeling difficult to deal damage to opponents who build RoA. As they have higher effective health after building RoA, I feel like 'my abilities do not...

View (4) Answers

Which way is Katarina facing when she ults?

If you need the enemy to be facing you for the Cassiopoia ult to be a stun, then which way is Katarina facing while she is ulting?

View (2) Answers

Question on Cassiopeia

I want to main Cassiopeia mid to climb the ladder, but i'm far from learning anything about her besides some combos. Should I just focus on tear for the majority of early, or is it better to constantly harass my opponent? What match-ups do I...

View (2) Answers

Who should i choose?

???????????????????????? [b]Best Option[/b] ???????????????????????????????????????????? [color=#0080ff]Ahri , Cassiopeia , Diana , Ekko , Vladimir[/color]

View (3) Answers

Who is the most OP champion in the game?

I am wondering who is the most OP champion to play. I wanna see how well I can do.

View (23) Answers

What are some fun or brainless champions?

I have no idea who I should buy; any suggestions?

View (8) Answers

Was Cassiopeia recently buffed?

Title.

View (1) Answers

cassiopeia at bot lane

has anyone tried to play cassiopeia at bot lane instead of an adc? as i don't main her nor am i at a high level of play i don't know how vibiable it can become. basicly here are some thoughts: 1. as an adc cass is a sustained damaged - low...

View (4) Answers

Timing of a DoTs first "tick"

So I wanted to ask this because I couldn't find it on LoLWiki. I've been under the impression that with DoTs the first tick of damage is done on application making it so that reapplying it in rapid succession will redo the first tick of damage....

View (0) Answers

Lich bane Cass

So I've noticed that every time you use [[twin fang]] on Cass, you get an auto attack in between the .5 sec cooldowns. So i was wondering how she would fair with a [[lich bane]] as compared to other build options

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Next AP Mid to learn and why?

Hey, so I can't really decide which champion to learn next after I have finished with Evelynn. I play AP Mid in a fixed 5vs5 team so I need champions who are valuable in organised competitive play. Champions I currently am able to play on a decent...

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