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LoL Champion Build Guides: Cassiopeia

Cassiopeia RP Cost 880 Cassiopeia BE Cost4800
Pick 77%
Win 52%
Pick 12%
Win 52%
Pick 11%
Win 51%
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Cassiopeia The Serpent's Embrace

Find the best Cassiopeia build guides for League of Legends Patch 10.20. The MOBAFire community works hard to keep their LoL builds and guides updated, and will help you craft the best Cassiopeia build for the S10 meta. Learn more about Cassiopeia's abilities, skins, or even ask your own questions to the community!


Season 8 Builds
LoL Champion Cassiopeia Build Guide

Cassiopeia mid (New runes)

Build by Polsejensen updated November 11, 2017
  • 7.22
Votes: 6
Views: 65,702
LoL Champion Cassiopeia Build Guide

Nexz Cassiopeia Top and Mid in depth [Patch 7.23]

Build by Nexlovely updated November 20, 2017
  • 7.22
Rating Pending
Views: 43,595
LoL Champion Cassiopeia Build Guide

Snakerunes, Cassio after the Runes rework.

Build by Guest updated November 14, 2017
  • 7.22
Rating Pending
Views: 8,906
Season 7 Guides
LoL Champion Cassiopeia Build Guide

A complete and detailed guide to master the Snake (**WIP**)

Guide by Aminumbra updated August 1, 2017
  • 7.15
  • In-depth
Rating Pending
Views: 27,230
LoL Champion Cassiopeia Build Guide

Cassiopeia, The Sneaky Snakey SoloQ Monster

Guide by Collamis updated March 26, 2017
  • 7.6
Rating Pending
Views: 3,693
LoL Champion Cassiopeia Build Guide

Took me to Master with Cassiopeia in S6, OTP Guide

Guide by Corp Blue Cobra updated February 12, 2017
  • 7.3
Votes: 22
Views: 637,649
LoL Champion Cassiopeia Build Guide

Throwing A Mid Lane Hissy Fit

Guide by DeathWalker1 updated November 29, 2016
  • 6.23
Rating Pending
Views: 29,384
Season 7 Builds
LoL Champion Cassiopeia Build Guide

[7.17]"There is No Antidote for Me"

Build by Lincoln878 updated August 26, 2017
  • 7.17
Rating Pending
Views: 6,642
LoL Champion Cassiopeia Build Guide

This is a stupid idea

Build by Guest updated August 5, 2017
  • 7.15
Rating Pending
Views: 2,281
LoL Champion Cassiopeia Build Guide

Cassiopeia Mid [S7]

Build by WhichG updated July 16, 2017
  • 7.14
Rating Pending
Views: 5,333
LoL Champion Cassiopeia Build Guide

CASSIOPEIA DEADLY BUILD

Build by HouYi updated July 8, 2017
  • 7.13
Rating Pending
Views: 2,386
LoL Champion Cassiopeia Build Guide

CASSIOPEIA TOP

Build by Guest updated June 24, 2017
  • 7.12
Rating Pending
Views: 2,650
LoL Champion Cassiopeia Build Guide

Cassiopeia Build

Build by Danny1819 updated April 19, 2017
  • 7.8
Rating Pending
Views: 2,117
LoL Champion Cassiopeia Build Guide

Cassiopeia

Build by Guest updated March 21, 2017
  • 7.6
Rating Pending
Views: 1,521
LoL Champion Cassiopeia Build Guide

BROKEN BUILD

Build by Frog Cake updated March 29, 2017
  • 7.6
Rating Pending
Views: 3,097
LoL Champion Cassiopeia Build Guide

S7 New build CASSIOPEIA

Build by Guest updated March 10, 2017
  • 7.5
Rating Pending
Views: 7,266
LoL Champion Cassiopeia Build Guide

The snake without an antidote

Build by nyle111 updated February 23, 2017
  • 7.4
Rating Pending
Views: 2,762
LoL Champion Cassiopeia Build Guide

AP Carry Cassiopeia

Build by PiTeRoVs updated January 19, 2017
  • 7.1
Rating Pending
Views: 21,596
LoL Champion Cassiopeia Build Guide

CASSIOPEIA HEALING GUIDE

Build by CassiopeiaONLY updated January 20, 2017
  • 7.1
Rating Pending
Views: 6,956
LoL Champion Cassiopeia Build Guide

Cassiopeia 1v9

Build by Korlo updated January 16, 2017
  • 7.1
Rating Pending
Views: 3,552

Cassiopeia Build Stats

Patch 10.20: 2078 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 52%

Win Rate 2773 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 58%

Win Rate 693 Games

Sorcery
LoL Path: Sorcery
LoL Rune: Phase Rush
Phase Rush
LoL Rune: Manaflow Band
Manaflow Band
LoL Rune: Transcendence
Transcendence
LoL Rune: Gathering Storm
Gathering Storm

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 52%

Win Rate 1200 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 52%

Win Rate 6972 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 51%

Win Rate 3873 Games

Flash Ignite

Third Best

Cassiopeia's 3rd Best Summoner Spells 52%

Win Rate 1445 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 51%

Win Rate 15361 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 55%

Win Rate 1439 Games

Sapphire Crystal Refillable Potion

Third Best

Cassiopeia's 3rd Best Starter Items 51%

Win Rate 1529 Games

Corrupting Potion

Trinket

Cassiopeia's Best Trinket 50%

Win Rate 10366 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 54%

Win Rate 3965 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 57%

Win Rate 1231 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 69%

Win Rate 1530 Games

  • 1
  • 2
  • 3
Patch 10.20: 2080 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 61%

Win Rate 94 Games

  • 1
  • 2
  • 3
Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Last Stand
Last Stand

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 51%

Win Rate 602 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 51%

Win Rate 156 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 50%

Win Rate 917 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Summoner Spells 54%

Win Rate 457 Games

Flash Teleport

Third Best

Cassiopeia's 3rd Best Summoner Spells 51%

Win Rate 272 Games

Exhaust Flash

Cassiopeia's Starters

Cassiopeia's Best Starter Items 50%

Win Rate 1706 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 52%

Win Rate 182 Games

Sapphire Crystal Refillable Potion

Third Best

Cassiopeia's 3rd Best Starter Items 49%

Win Rate 104 Games

Corrupting Potion

Trinket

Cassiopeia's Best Trinket 59%

Win Rate 153 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 48%

Win Rate 1201 Games

Warding Totem

Third Best

Cassiopeia's 3rd Best Trinket 53%

Win Rate 654 Games

Farsight Alteration
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 71%

Win Rate 111 Games

  • 1
Patch 10.20: 2080 matches scanned * Each section of the build is rated independently of the others

Cassiopeia's Runes

Cassiopeia's Best Runes 62%

Win Rate 52 Games

  • 1
  • 2
  • 3
Sorcery
LoL Path: Sorcery
LoL Rune: Phase Rush
Phase Rush
LoL Rune: Manaflow Band
Manaflow Band
LoL Rune: Transcendence
Transcendence
LoL Rune: Gathering Storm
Gathering Storm

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Second Best

Cassiopeia's 2nd Best Runes 56%

Win Rate 90 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Third Best

Cassiopeia's 3rd Best Runes 53%

Win Rate 60 Games

Precision
LoL Path: Precision
LoL Rune: Conqueror
Conqueror
LoL Rune: Presence of Mind
Presence of Mind
LoL Rune: Legend: Tenacity
Legend: Tenacity
LoL Rune: Coup de Grace
Coup de Grace

Domination
LoL Path: Domination
LoL Rune: Ravenous Hunter
Ravenous Hunter
LoL Rune: Taste of Blood
Taste of Blood

Cassiopeia's Summoner Spells

Cassiopeia's Best Summoner Spells 49%

Win Rate 1555 Games

  • 1
  • 2

Second Best

Cassiopeia's 2nd Best Summoner Spells 54%

Win Rate 186 Games

Flash Ignite

Cassiopeia's Starters

Cassiopeia's Best Starter Items 48%

Win Rate 2463 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Starter Items 54%

Win Rate 337 Games

Sapphire Crystal Refillable Potion

Third Best

Cassiopeia's 3rd Best Starter Items 52%

Win Rate 310 Games

Corrupting Potion

Trinket

Cassiopeia's Best Trinket 48%

Win Rate 1303 Games

  • 1
  • 2
  • 3

Second Best

Cassiopeia's 2nd Best Trinket 55%

Win Rate 430 Games

Farsight Alteration

Third Best

Cassiopeia's 3rd Best Trinket 52%

Win Rate 192 Games

Oracle Lens
Don’t forget
to Buy Wards

Cassiopeia's Ability Order

Cassiopeia's Best Ability Order 72%

Win Rate 102 Games

  • 1
  • 2

Cassiopeia Skins

Cassiopeia's Abilities

Ability Range Cost Cooldown
Cassiopeia's Serpentine Grace
Serpentine Grace Cassiopeia's Passive Cassiopeia's Passive
Self
Cassiopeia's Passive
Cassiopeia's Passive
Cassiopeia gains 4 Movement Speed per level. Cassiopeia cannot purchase Boots items.
Q
Cassiopeia's Noxious Blast
Noxious Blast Cassiopeia's Q Ability
850
50 / 60 / 70 / 80 / 90
3.5
Cassiopeia blasts an area with a delayed high damaging poison, dealing 75 / 110 / 145 / 180 / 215 (+90% of ability power) magic damage over 3 seconds and granting her 30 / 35 / 40 / 45 / 50% movement speed which decays over 3 seconds if she hits a champion.
W
Cassiopeia's Miasma
Miasma Cassiopeia's W Ability
700
70 / 80 / 90 / 100 / 110
24 / 22 / 20 / 18 / 16
Cassiopeia spews venom in an arc in front of her, leaving toxic clouds for 5 seconds. Enemies in the cloud take 20 / 25 / 30 / 35 / 40 (+15% of ability power) magic damage per second, are slowed by 40 / 50 / 60 / 70 / 80% (decays over the duration) and are grounded, prohibiting the use of movement abilities.
E
Cassiopeia's Twin Fang
Twin Fang Cassiopeia's E Ability
700
50
0.75
Cassiopeia deals 48 (+4x champion level) (+10% of ability power) magic damage to her target.

If the target is poisoned, Twin Fang deals 10 / 30 / 50 / 70 / 90 (+60% of ability power) bonus magic damage and restores 12 / 14 / 16 / 18 / 20% of Cassiopeia's ability power to her as health. This heal is 75% less effective against minions and small monsters.

If Twin Fang kills a unit, its mana cost is refunded.
R
Cassiopeia's Petrifying Gaze
Petrifying Gaze Cassiopeia's Ultimate (R) Ability
825
100
120 / 100 / 80 / 80 / 80
Cassiopeia releases a swirl of magical energy from her eyes, dealing 150 / 250 / 350 (+50% of ability power) magic damage to all enemies in front of her. Enemies facing her are stunned for 2 seconds, while enemies facing away are slowed by 40% for the same duration.

Questions About Cassiopeia

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