Fangs of Du Couteau: The Complete Cassiopeia Guide
Build Guide By uramakyo
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Cassiopeia Build Guide By uramakyo
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Recommended Items
Runes: CONQUEROR
1
2
3
Precision
Resolve
+9 Adaptive (5.4 AD or 9 AP)
+9 Adaptive (5.4 AD or 9 AP)
+15% Tenacity/Slow Resist
Spells:
1
2
Agressive
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![LoL Summoner Spell: Flash]()
![LoL Summoner Spell: Ignite]()
Flash
Ignite
Items
FIRST ITEMS
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CORE ITEMS
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BOOTS (READ NOTES)
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SITUACIONAL ITEMS
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Ability Order
Serpentine Grace (PASSIVE)
Cassiopeia Passive Ability
Threats & Synergies
Threats
Synergies
Extreme
Major
Even
Minor
Tiny
Show All
None
Low
Ok
Strong
Ideal
Extreme Threats
Ideal Synergies
Zed
One of your worst matchups. His R is undodgeable, his shadows bypass your W, and he has enough burst to kill you before Conqueror stacks up. Zhonya's is mandatory and even then it's miserable.
Amumu
The dream combo. His R hits everything in range, and if enemies try to run away they walk straight into your W and poison cloud. You R them while they're still rooted — near-instant stun chain with zero counterplay in tight spaces.
Synergies
Ideal
Strong
Ok
Low
None
Amumu
The dream combo. His R hits everything in range, and if enemies try to run away they walk straight into your W and poison cloud. You R them while they're still rooted — near-instant stun chain with zero counterplay in tight spaces.
Champion Build Guide
Fangs of Du Couteau
The Complete Cassiopeia Guide
A champion defined by patience, precision, and poison.
Season 2026 • Patch 26.9 • Mid Lane
Why Play Cassiopeia?
Cassiopeia is one of the highest DPS mages in League of Legends.
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PROS
+ Massive sustained damage + Strong anti-dive tools + Excellent scaling + Melts tanks + Dominates long fights |
CONS
- No mobility - High mana dependency - Very punishable positioning - Mechanically difficult - Weak from behind |
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FLASH + IGNITE Best into:
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FLASH + TELEPORT Best into:
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Doran's Ring Cassiopeia. Best into:
Cassiopeia burns mana extremely fast early game, making Doran's Ring essential.
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Archangel's Staff Best into:
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Liandry's Torment Best into:
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Rylai's Crystal Scepter Turns poison into permanent slows. Amazing for kiting. |
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Zhonya's Hourglass Essential against assassins and burst. |
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Banshee's Veil Strong against engage and pick comps. |
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Rabadon's Deathcap Huge AP spike for late game. |
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Void Staff Necessary against magic resist stacking. |
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Boots of Swiftness Best into:
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Gluttonous Greaves Best into:
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CONQUEROR Best standard rune page.
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Stormraider's Surge Movement-focused setup.
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DEATHFIRE TOUCH Maximum damage page.
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Early Game
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Cassiopeia's early game revolves around controlled trading and mana management. Goals:
Tips:
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Mid Game
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Cassiopeia becomes extremely dangerous after completing core items. Main objectives:
Teamfight priorities:
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Late Game
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Late game Cassiopeia is one of the strongest DPS champions in the game. Your role:
Positioning matters more than mechanics late game. If protected correctly:
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Thank You For Reading
“The serpent never stops evolving.”
This guide will continue being updated patch after patch to keep everything accurate for the current season.
Matchups, runes, builds, itemization and tech choices may change over time, and this guide will evolve with them.
Follow My Content
If this guide helped you, you can find more Cassiopeia content, ranked gameplay and educational streams here:
Every patch changes the Rift.
Every matchup changes the lane.
But poison always finds a way.
See you on the Rift.
uramakyo
Cassiopeia Guide
Fangs of Du Couteau: The Complete Cassiopeia Guide
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