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Stacking R depends on the fight itself, if there is a squishy target that is worth killing (ADC or some other high damage low hp role) then yes it definitely is. In essence if you know you aren't going to run out of mana for the fight, then by all means stack the R.
Hope this helps!
Just to help you increase your knowledge of Kassadin, he is actually not the father of the void. But actually the defender of Runeterra from the void. That's why he's the enemy of Malzahar, who is the Prophet of the Void and almost like a person that has lost all hope and surrendered to its powers. That gives me an idea, I should probably make a new chapter and make that his lore chapter. Thanks for the idea! :D