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1. Cooldown reduction Glyphs is a waste of rune space. Karthus only has 2 spells that would need CDR for, and they really don't need it. Your wall Gets a low enough CD and so does your Req. I'd rather use AP per level Runes or flat AP instead of CDR. The health isn't necessary either considering if your good at zoning you won't need it. You need to be able to hit hard.
2. Im a firm believer of a 21/0/9 Karthus. Its just a better mastery setup imo for him. But 9/0/21 is good too.
3. Other than that, niceo!
20-2-10 win.
P.S. if anyone knows how to post pictures of my match history then PM me.
Awesomesauce? - More like winsauce.