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The only time you go to your base is for items and mana, because if you press W (the heal) just once it refills EVERYTHING!
Q can take out half of the champions HP, then all it takes is E & R and they're dead + CDs are down because of R. Then maybe just a heal and you're good to go.
There is an item this is extremely important to this build that is worth mention and that is Thonmail. If there are champs with fast AS and high AD you can use meditate and usually beat out their hits, while thornmail is returning 30% of what they are dealing you while you wait for alpha strike to cooldown. This is great especially for a 1v1. I have 1v1 AD Yi's and won. Alpha Strike> Meditate> Alphastrike, while maybe mixing in an Ignite and having the ult on in case I need to get away.
if ur playing ap yi u shouldn't even be in melee range half the time though aside from the first alpha and maybe a lichbane proc
May AP Yi be victorious! (but wuju pass him that potion?)
If the enemy everytime tries to stun you in your meditate, then get Zhonya's Hourglass first. This gives you already there 2 additional seconds, which can mean win or loss at this point.
http://img151.imageshack.us/img151/8821/masteryiap.png