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also if you need any more help you can pm me
This is why I personally thing Flash is VITAL on Karthus, so you can position where you want you're passive to take effect, also so you can escape as Karthus is a 'statue champ'.
It's not a bad guide, but I think that Flash would improve it, and if you can get blue buff you mightn't need Athene's Unholy Grail, especially given you can cast spells for free during Death Defied.
I see this definently working for some normal games but perhaps not ranked, but still, it doesn't say ranked so I won't downvote.
-boots is a little late
-no real escape, if a jungler ganks you will most likely die
-I suggest replacing ignite with flash for escapes OR getting boots a little bit early