Usually go ArmrPen marks, mana seals and glyphs and armorpen quints. Thats my typical range carry. If im playing a melee carry, yi, or gankplank, i change the mana seals for dodge.
The battleroom is ready. Liqur's hands are steady. The enemy is deadly.

I believe that you'll find any viable replacements in the rune ranks section of my rune guide.
(I don't do this to advertise myself, I hope noone minds)
(I don't do this to advertise myself, I hope noone minds)
"every now and again you come across a game that has so little emotional connection to who you are that you end up standing there, gazing at the screen and saying "I'm just pressing buttons and my life has no meaning,"" - Colin Campbell
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So last patch went through a balance in how mana regen works.
Before it felt kinda mandatory for AD carries (Ashe, Yi, Ez, Cait for instance) to pick some mp5 runes in order to have a good spammability.
But what about it now ?
Have you considered changing them ?
For which one ?
Personnaly, I'm considering the %crit runes.