Usually go ArmrPen marks, mana seals and glyphs and armorpen quints. Thats my typical range carry. If im playing a melee carry, yi, or gankplank, i change the mana seals for dodge.
The battleroom is ready. Liqur's hands are steady. The enemy is deadly.

I believe that you'll find any viable replacements in the rune ranks section of my rune guide.
(I don't do this to advertise myself, I hope noone minds)
(I don't do this to advertise myself, I hope noone minds)
"We've had a few gloomy years with bad console ports, and what do we get in the light at the end of the console-tunnel? A tablet OS ported to PC." - Atlas Tasume, on Windows 8
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So last patch went through a balance in how mana regen works.
Before it felt kinda mandatory for AD carries (Ashe, Yi, Ez, Cait for instance) to pick some mp5 runes in order to have a good spammability.
But what about it now ?
Have you considered changing them ?
For which one ?
Personnaly, I'm considering the %crit runes.