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And yes I am level 30, have been for several months, and assassins are easily avoided if you are vigilant enough. For early defence, i also said that no build for vayne is solid and by the book, and that often getting defence items early, based on the enemy team, can be a good choice.
Believe me I do agree that anything above 2.0 atk speed is not helpful, but these items and runes take you to 2.1 atk speed, at which point i do not go on to add another attack speed item.
And finally, for the runes, I stated that i was not a big fan of them, and to tweak them to your delight.
The second problem I have is that you have no defense until mid-late game. You will get destroyed by competent assassin players, but I can probably safely assume you are non-30 or low elo and don't see them.
Last issue I have is that you wasted your glyph and seal slots. Mana regen or flat magic resist would be a much better use for them, seeing as the attack speed runes are so weak.
If you didn't know this, champions have base attack speed bonuses. IE, at level 18 vayne has 55.8% bonus attack speed. This amount does not stack multiplicately with items.
TLDR: Too much attack speed on this champion.