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To maximize damage against champions, you would ideally find out exactly how much AP you need at level 5 to kill the casters, then fill everything else out with more magic pen. You could free up more runespace by gettign a second doran's ring (to cover both ability power and mana regen) before your tear.
Okay I took this into consideration, and crunched the numbers for you.
Minion:295 hp, 0 MR. Pillar of Flame, 125(.60 AP ratio). Sear, 70(.55 ratio) Blaze, 5.6/tick. Lvl 4, 37 AP.
295 - (125+(37*.60) - (70+(37*55) - (7*5.6)
295 - (147.2) - (90.35) - (39.2)
295 - 276.75
= 18.25
Using Glyph of Potency would add a total of 3 ability power vs Glyph of Force, which would equate to roughly 1.6 more damage.
I hope this answers your question, thanks for asking. :)