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Taking 1 point in Tides of Blood decreases your DPS, and only makes you weaker. The amount of E spam it takes to equate to the same amount of health lost from your W is roughly 8. Sanguine Pool takes 20% of your current health to use, and most of the time you don't have that much health to spare; defeating the purpose of high ranks in it. It barely does ****ed up damage since the nerfs (not in a good way), and it's just overall not a great spell to max.
Maxing
Also, Flat AP runes work better, because you don't need the minimal amount of AP it provides you with later in the game. Scaling/Flat runes fall off at around 9. That's when Vladimir is at his best, and even at that; the increases from the Scaling runes is so minimal its not worth it. You want your eggs to be in the basket that matters. Flat runes ensure Vladimir a steady early game, and pave the road to victory for a phenomenal late game. Taking scaling runes encourages passive gameplay, which is not what Vladimir is about.
Additionally, Spell Penetration (
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