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Your runes are horrible, might as well get some mana regen instead of flat mana
Mejais is a good idea if you know you wont die, i agree on that part, but your other items are extremly expensive, if you go bot with a carry you shouldn't be taking creeps, and if you do you wont be letting your true carry rise up to their potential.
Your masteries contradict your build.
Why go with an offensive ap build while you take utility masteries ?
This should really be reworked in an ap janna guide, otherwise it's just plain wrong.
Your runes are off (you did warn us tho) and q should be prioritized on champions, creeps should be allowed to go where they want, just last hit them for the gold (if mid) or leave them for the ad carry @ bot.
Finally, I'd suggest to prioritize mana manipulator as a first item, as it will help a lot in bot, and will let you get it's upgrade (it's awesome on Janna) later.