Flat mana for lane crushing.
Scaling mana for late game.
Scaling mana for late game.

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You definitely don't need the mana regen or the AP runes. I'd suggest health/lvl yellows and MR blues as possibilities.
I've heard mana runes work very well but I've never tried them or looked at the math behind it. Don't have enough IP or runepages to get them.
I've heard mana runes work very well but I've never tried them or looked at the math behind it. Don't have enough IP or runepages to get them.




Ryze is my main magic damage champ and these are the runes I run on him.
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*Listen to me, I'm VERY knowledgeable in runes(check my only guide and you'll see)*
I use
MrP marks
Mana/lvl seals (armor would be better if you face AD)
Flat Mana glyphs
MS quints
I take mana/lvl seals because they give 3.06 times more than the flat ones.
I don't take mana/lvl in glyphs because they only give 2.27 times more than the flat ones.
It's a pretty good combo.
I use
MrP marks
Mana/lvl seals (armor would be better if you face AD)
Flat Mana glyphs
MS quints
I take mana/lvl seals because they give 3.06 times more than the flat ones.
I don't take mana/lvl in glyphs because they only give 2.27 times more than the flat ones.
It's a pretty good combo.
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Yeah but at level 1 the Q is just focking incredible with flat mana :)

http://www.mobafire.com/league-of-legends/build/duffs-336706
Come hang out when I'm streaming! http://www.twitch.tv/dufftime
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Anyway, I was running my standard caster runes: MPen reds, Mana regen per lvel yellows, ap per lev blues, and ap quints. I really love his gameplay, and wanna see him at his full potential. The guides seem to be pretty mixed on what runes to run on him. Some say ALL MANA, some say standard caster just with AP quints replaced by MS, some say all MPen, etc. I have a ton of IP, and would be willing to invest in mana runes if u think they're worth it for him. Just trying to figure out what runes are best for this champ i love!