So I'm not the most experienced Akali player ever, but lately I have been playing her a lot and this is just my preference of runes/masteries/summoner spells for a few reasons. To me, Akali is all about early game, having a death can really hurt before level 6(well especially before 6). I chose all the health runes I did because they help her early on as well as late game because i don't usually get any health items except Rylai's Crystal Scepter, so the health is much needed for my playstyle. I like Ghost/Exhaust because they are great for chasing and running, they are extremely versatile. Exhaust also really helps in early game fights. Once I hit 6, I'll either try to kill the enemy champions in my lane if it seems like we have a good chance, or go back and spend the minion/champ killing money. I then usually try to gank my lane if they are being overconfident, or another lane if they aren't being careful while I'm MIA. If I do well early on I'll get a Mejai's, if not I'll just stick with the Rylai's for its slow, which is amazing for ganking which, IMO, Akali is amazing at... minus if the enemies are fed. I then go Guinsoo's because the upgrade from the pickaxe and blasting wand is amazingly cheap for 400 gold, even without the 8 stacks. Next I go for Zhonya's, because by now if you are having a good game, you'll get targeted and AOE will hurt even in your shroud. Then I take the gunblade because after its buff, it is an unfed bloodthirster with an active, along with the ability power you get from it. And lastly, just for decent and more constant damage, I get the cleaver. I'm not saying any game will last that long, most won't even last close to that long, but it is just how I play with the few games that do last long enough(somehow). If you need more health you could go Frozen Mallet instead of some of the other less useful items like the gunblade, or even get another Rylai's. I shy away from using Lich Bane(or trinity force) except on champions like ez, eve, poppy, and nasus with extremely constant, or on hit-effect abilities.
Feel free to comment and give suggestions because like I said earlier, I'm not the most experienced Akali even though she is my favorite champion now because I enjoy her playstyle a lot. Laterz...


Just ignore this guide, it was a long time ago and I have learned a lot about the game since, also I have moved away from Akali.