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I personally don't believe that focusing on defensive approaches is the most effective when it comes to Darius, also in terms of masteries. Sure, it can work to a degree for some, but as I stated in my guide, one needs to bend the build (masteries included) more towards the offensive side than the defensive one in order to fully benefit from Darius' kit. This is also true for the gameplay itself, but with smart plays of course. I think that 21/9 is the strongest for Darius because you boost all aspects of damage, which as I mentioned makes the difference between a Darius and a Dariusaurus. What I'm really saying is that Darius is highly dependant on it. With Darius being a natural executioner with his ultimate and passive,
-Defarakka.