The Guide is nice, but you forgot how you can recall in peace pres Q and quickly B.
Imo i found a few flaws
Twitch CAN be a hybrid carry, but items don't really synch with the masteries, twitch needs at least 9 in defence
1 Rank of Ambush is enough
Maxing out Expunge should be main priority
Maxing out Defiblirating Poison should be second
Overall good guide, you'll get +1 from me right now but i espect some inprovements.

Full offense masteries seem strange.. I see you put thought and detail into your guide though I feel bad that you got trollvoted.

Turn on Comment Required to Vote, so you don't get troll-downvoted. I learned it the hard way :/

Sorry, I had to -1 you for ignite and your choice of items at the start. I once used Pickaxe + boots, but it's nowhere near as effective as Prospector/Boots/2 potions combo.

No one should be using ignite on Dominion IMO EVER. Kills help. But for the fight at the windmill, Ghost + Exhaust is better for the team.

yeah there are better ways to play twitch with my build i went 32/6/5 and had 2543 points

Thanks for the comment. I added that in.

nice build... i upvoted it but you might want to throw in a little survivability such as a frozen mallet just a suggestion