This guide isn't in any way meant for competitive play, I've played Akali for quite awhile now, and I find that this build is the most effective build on Akali. To play Akali this way you have to be able to effectively use your Twilight Shroud because you'll be so squishy. With this guide you will be able to decimate your opponents, while healing for almost half of your hp with your R.

Without farm, you won't ever get the farm you need for this build, if you farm, and play smart then you shouldn't have any issues dominating the game if you use your twilight shroud correctly.

In early game you want solo top or mid, you need to farm non-stop while harassing your opponent with your Q -> Auto Attack -> E, but be careful you won't reach your full potential until you get your ultimate.

In mid game you should have your ulti, now it's fun time. From now on your basic combo should be Q -> R -> Auto Attack -> E, repeat until dead. If you get into a situation that you don't want to be into just throw down your W and run in the opposite direction, or flash away over a wall. Your job in team fights is to take out the squishy champions and then finish off the remaining ones. After your first gunblade or two a great thing to do when your low on hp is to go and kill wraiths or wolfs and make sure to spam Q and E, maximizing your vamp.