This is my first guide!
So, it might just be an eh-eh guide.
So, I am gonna add in some stuff here:
Even in her youth, Karma exhibited almost superhuman composure. While her peers explored the torrent of emotions that came with adolescence, Karma meditated in the Lotus Gardens. She was convinced that the true path to enlightenment was a journey inward, to a place within the self, overlooked by most. She exuded such inner contentment that she quickly became a go-to mediator and confidante in her village. Her instructors used to say: "That girl can not only weather a storm, but calm it." Karma did not live extravagantly; her parents owned a local business selling antiques in the Navori province and they often struggled to provide for themselves, though they did so with cheery optimism. Her most prized possessions were two exquisite fans taken from her family's shop.
When Noxian troops invaded southern Ionia, her village was one of the first to fall. The villagers who survived the assault were captured by Noxian forces. It was then that Karma found her calling. By exploiting the insecurities of the Noxian commander, she negotiated the safe release of the villagers to the northern lands. She was present at the Placidium, where the Elders had considered surrender until Irelia's impassioned last stand renewed the Ionians' hope. Karma used this hope to solidify the Elders' commitment to remain defiant against the Noxian onslaught. For her devotion and charisma, Karma was made the figurehead of the Ionian resistance. She never compromised, and she shared every hardship with her people, even when it came to combat. By tapping into her inner resilience, she discovered that she could bring great force to bear against her foes on the battlefield. She modified her fans into lethal implements, and was tutored by Janna to enhance their effects. The Noxians called her "The Enlightened One," a nickname she embraced, and one which they would come to dread. She joined the League to represent Ionia in the ultimate political arena.
All of Karma's abilities have both an offensive and a defensive component, accentuating the dualism of her character.
Karma is one of few champions to have an Art Spotlight, along with Cassiopeia, Renekton, Swain and Trundle. Karma, however, was the first to feature it even before her official arrival.
The name Karma, and the title, "The Enlightened One" is related to the Buddha, which is Sanskrit for "enlightened one." The doctrine of karma, the effects good or bad actions have on a person, is also prominent in Buddhist, Hindu, and Jain beliefs.
Karma's quotes,"An enlightened decision,""Onward always,"To conquer oneself is to conquer all," and "You interrupted my meditation for this?" Are all connections to the things that the Buddha did.
Karma's concept art resembles Edea from Final Fantasy VIII.
Karma was designed by Coronach.
Karma appears to wield Eastern fighting fans which are exceptionally similar in style to the "Steel Fans" which Kitana wields in the Mortal Kombat series.
Karma is the only champion whose three main abilities have six ranks.
Karma is the second champion after Udyr to lack a proper ultimate skill.
This is debatable. While her ultimate doesn't obey the rules of a standard ultimate as far as leveling is concerned, she still has one, unlike Udyr who has 4 skills with 5 levels each

I picked these runes because they apply well with Karma. I have been using them for a while, when Karma came out, I tested them on her, and they worked greatly.

9/0/1
Attack: AP stuff
Defense:---
AP: Necessaries

The basic Karma items, Health to keep her living, AP to boost her spells, and CDR to, well, Cooldown Reduce.

The necessary order...just gets you more kills.

Flash-You can shield then flash, gets you away fast.
Exhaust-Shield/Exhaust/Slow, your free.

This is my first guide, so, uh, I bet its kind of sucky but yeah...