Hello I am Darkrocmon a Solo Queue Nobody (thanks trolls). I am slightly known for playing unconventional champs or champs in uncoentional roles just like in my Katrina Guide which is for jungling her. In this guide I will show you how I personally make Solo Que hell for people with Karma.

As an AP champ no matter the lane I choose the same marks 9x Greater Mark of Magic Penetration
If I am solo top I choose 9x Greater Seal of Armor
If Mid I choose 9x Greater Seal of Replenishment
Either lane I take 9x Greater Glyph of Scaling Magic Resist although you can opt for some Greater Glyph of Cooldown Reduction
For both lanes I choose 3x Greater Quintessence of Ability Power

For solo top I choose 9/15/6 picking up all the magic friendly masteries in Offense Some nice defensive masteries and CDR in Defense and some Mana Regen and lower CD on Flash in Utility.

For Mid I choose a standard Mage setup.

Item choice is really large and you can really pcik up anything as long as you have some decent CDR and defenses.

For me i always start with her E then geting 2 quick points into her Q for poking and healing. Geting a quick point in W whenever my jungler comes o gank or at lvl 8 leveling it last. Oh and btw never level Karmas R ;)

Q - Use this for a heal but when you do make sure you can poke with it if you are just healing your self...if not hit your teamates.
W - Nice slow and speed up but dont really level this untill the end make sure if you are chasing some one to land this on them or a nearby creep to either speed you up or slow them down and speed you up.
E - use this to shield that pesky Karthus Requiem to harass that dumb Riven last hitting creeps or to even shield creeps to push the turret more you can also use this when you are dueling some one to own them most people dont know Karma or her skills and wont realise they just got WREQed (btw not just a cool way of spelling but a nice late game combo)
R - Karmas Bread and Butter spell a level 1 ult that you never have to level. make sure to build some CDR so you charge this faster.

So if you decided to skip the guide (shame on you its short) or you have read it all (congradulations you have a 5th grade reading level or higher) you have learned all i know of Karma and how to play her. I hope you try her out and be warned...you will get flamed and trolled for playing her but she is actually good...will write a new guide for her when they make the remake and for the new masteries.