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Ryze Build Guide by Kengi
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M.Pen = you don't need the other primary runes
Replenishment vs clarity
You need it early game and wont have to worry about it late game.
9 Mana per lvl = More damage
Movement speed = MS is a important factor that ryze lacks, this gives him a boost to keep up or get away.
Go B for Tear of the goddess.
3rd and 4rd item:
When getting fed: Rod of ages
When having a hard time: 1st deff item:
Frozen heart = when laning against (or getting ganked allot by) physical damage
banshee's veil = when laning against (or getting ganked allot by) magic damage
5th and 6th item:
same order as before:
2nd Rod Of Ages or 2nd deff item (banshee or frozen heart, what you didn't choose first)
I don't know what items to trade in after this, please suggest some in the comments. (1 time i had 5k and didn't know what to do >.<)