This build is intended to fit Nasus into an offtank/DPS role.

As for Runes, I choose armor penetration Marks for obvious reasons, flat mana Glyphs to address mana issues early game and to synergize with Manamune, flat armor seals for some early game defense and to compensate for only having 1 armor item, and flat health Quintessences for more survivability early game.

For masteries, I usually go more tanky as I like to stay alive. Honestly up to you for the masteries department, this is just my personal preference.

to address any mana issues Nasus might have, coupled with the passive which gives him more attack damage. This synergizes well with mana Glyphs. Boots, most of the time are, however, if you are facing off against a heavy AD team you may want to go with. I take, which I keep for a while to add more damage to my Q before upgrading it toafter building up a bit of defense. I preferfor the cooldown reduction, adding more mana for's passive, good armor and the passive slowing effect.for added magic resist and health regeneration, and finally, which a lot of players typically do not get, but I think Nasus does very well with this item. It gives Nasus everything he needs. More attack damage, more crit, more armor penetration as well as cooldown reduction so you can spam your Q more often. In addition, the use on this item is very helpful as one of Nasus' downfalls is his lack of engage. Turn this on when charging into a fight or chasing down enemies who turn and run when they see you coming. The attack speed is also an added bonus.

For summoner spells I take Ignite and Ghost. Ghost for chasing down and running away, and Ignite for those pesky runners/healers.

A think Nasus benefits from a well-rounded build more than going too heavily in one direction in terms of damage or defense. Farm your Q and kick some ***us!