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My Rune Setup Was:
Marks: 9x Greater Mark of Attack Damage (8.5 total)
Seals: 9x Greater Seal of Armor (9 total)
Glyphs: 9x Greater Glyph of Scaling Ability Power (28@18)
Quintessences: 3x Greater Quintessence of Spell Vamp (6% total)
That added Spell Vamp synergy with Omen of Famine really helps keep you healed up.
I followed the item build up until the QSS. I instead went for an Essence Reaver (which I know is a new addition since the publishing of your build). The Essence Reavers gives you much needed life steal to stay in the game later on, helps fuel your Muramana attacks to stay toggled on,and it puts you at the CDR cap (5% over oh well).
To finish off, I was working toward a Trinity Force (already had the Sheen in my last slot). Needless to say, I scored a quadrakill (and our beginning team comp was horrible, but crazy carry Yorick was too busy putting their corpses into graves and so we won!)
22/8/22