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Masteries, why you add +1 to expanded mind, if you dont max it, more usefull is +1 to clarity if you want use it.
M. penetration quints are not good idea if you get void staff in late game, better are ap or clear hp to avoid squishness.
There are a lot of champions who can avoid Karthus ultimate: vlad, kass, sivir etc, and items like zhonya or banshee. Hope you will add more info to description, atm dont vote, becouse want see more.