Well, i made this guide to help one friend that was using AP on ryze and loosing all the games, as i plyed ryze several times when he wasnt a mana user but a AP user it was good, but now ryze is only mana, and its better becouse there are several items with mana and resists and health too.

My runes explanation is: more mana more dmg, more regen = harassment with Q, and more hp = more time in lane, easy.

This is my custom items, when the enemy team have 1 tank, 2 Ap and 2 AD, if they dont have AD dont build armor, if they dont have AP its different, u should build the banshees veil if they have a lot of cc, and then build armor.

Well, this is the fun part, with ryze u can just harass then before the team fight begins, ur Q now have LOW CD and with ur passive u can just spam it, and with the mana build u will never have mana problems, I almost always do a good score with ryze if I dont engage before tank, that sometimes i cant do :P

well i know its a weak explanation about the build but theres not much to say about it, if u want to know anything about how i play just post something.
Thank you,
Squeezya.