Hey, this is my first guide on here and feel this build works really well. I got my first Pentakill with vayne the day she was released for EU. I hope this guide will help you achieve the same :)

PROS:

FAST!!!!!!(no really, she's rapid!)
Great Harrasser
Amazing throughout game
huge damage with silver bolts and tumble combo
She can roll ;o

CONS:

Squishy early game
Has a Lady GaGa skin :|

This is the item sequence I go with almost every game.

It depends on what you want from your build, i normally go Infinity Edge straight after Trinity Force for the extra pew damage.

SHEEN!!!!: sheen adds so much "pew" to vayne especially early game. Tumble activates sheen allowing the next auto attack to deal insane damage.

BOOTS: i chose Berserker's Greaves for the extra attack speed for early game harrassment.

When in a team fight i tend to hang around the edges and follow the tanks lead. When a wall is nearby i do my best to roll next to the enemy to get a nice shot with Condemn.

Dont be afraid to chase an enemy for longer than you would with any other champion. your passive is extremely good in these situations and always try and get that last silver bolt in for added damage

Remember this is my first guide, please comment and vote up or down. Please give a reason for downvoting so I can improve.

Thanks