First off, I am not suggesting that this is the only viable build, only that i like it best.

Since vayne dosent need very much armor pen, due to her silver bolts, i dont have Armor Penetration on Quints and Marks. My choice of AD and AR gives a very good early game boost, where vayne is weak. The seals are pretty self explanatory. Everyone likes armor right? I purposefully do not have Flat MR glyphs, since I am not facing mages (in ranked.) MR per lvl i think are the best glyphs in the game.

Masteries are standard, and pretty self explanitory.

Although maxing your Q first might not maximize your damage, it helps your lane poke, helps you stealth more often because of CD reduction, and over all more mobility. Maxing Silver bolts second helps with penetration on somebody like allistar, leona, or anybody else with much armor. I max condemn last because leveling this ability up doesn't really help you. The main purpose of it is to push people back, and to stun them. Maxing it does neither extend push back, nor extend the duration of the stun.

Exaust is a fantastic carry spell in general. Helpe in lane against other ad attackers, and slows for more kills. I really really like ghost on pretty much everyone but supports or mages. I love the extra move speed for chasing.

Pros:
1. Not bad lane, good poke.
2. Incredible three hit burst.
3. Fantastic late game.
4. Stealth to keep you safe.
5 Very little attack damage reliance

Cons:
1. Very Squishy.
2. Oracles destroys her.
3. easy to chase down with more than two pursuers.

In my opinion, farming your lane and not feeding is far more important then getting fed. A score such as 1/0/0 with 140 farm, is far better than 3/0/0 with 60 farm. A kill is equal to about 20 minion kills. Do the math, farming is better.

All in all vayne is the best carry in the game. Great damage some cc, and a stealth. leave a comment please :)